[Intraosseous metastasis of K27-mutant glioma].

Autor:	Ryzhova MV; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Galstyan SA; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Starovoitov DV; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Snigireva GP; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Zubova IV; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Golanov AV; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Pronin IN; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Pavlova GV; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Mertsalova MP; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Belov AI; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Kalinin PL; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia., Serova NK; Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Arkhiv patologii [Arkh Patol] 2021; Vol. 83 (3), pp. 40-44.
DOI:	10.17116/patol20218303140
Abstrakt:	Glioma metastasis outside the central nervous system is a quite rare phenomenon. The disease in a young woman manifested itself as back pain and loss of vision in the left eye. Magnetic resonance imaging (MRI) revealed a tumor of the optic nerve; positron emission tomography showed multiple secondary bone changes. At the same time, MRI detected no signs of neoplasm in the midline brain structures (the brain stem and subcortical nuclei) and spinal cord. Two biopsies (superior iliac spine trephine biopsy and optic nerve tumor biopsy) were performed. There were similar histological tumors; the optic nerve tumor was found to have K27M mutation in the H3F3A gene, whereas the metastatic tumor lacked this mutation (possibly due to the quality and quantity of DNA isolated from the tumor cells). The interesting features of this case are the simultaneous detection of primary and metastatic tumors before receiving any treatment and the absence of the K27M mutation in the H3F3A gene in the metastasis.
Databáze:	MEDLINE
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