A Toolkit and Framework for Optimal Laboratory Evaluation of Individuals with Suspected Primary Immunodeficiency.

Autor:	Knight V; Department of Pediatrics, Section of Allergy and Immunology, University of Colorado School of Medicine, Aurora, Colo., Heimall JR; Division of Allergy and Immunology, Children's Hospital of Philadelphia, Perlman School of Medicine at University of Pennsylvania, Philadelphia, Pa., Chong H; Division of Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pa., Nandiwada SL; The Texas Children's Hospital, Section of Immunology, Allergy and Retrovirology, The Baylor College of Medicine and the William T. Shearer Center for Human Immunobiology, Houston, Tex., Chen K; Department of Immunology, University of Washington and Seattle Children's Hospital, Seattle, Wash., Lawrence MG; Division of Asthma, Allergy and Clinical Immunology, University of Virginia, Charlottesville, Va., Sadighi Akha AA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn., Kumánovics A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn., Jyonouchi S; Division of Allergy and Immunology, Children's Hospital of Philadelphia, Perlman School of Medicine at University of Pennsylvania, Philadelphia, Pa., Ngo SY; Department of Pediatrics, Section of Allergy and Immunology, University of Colorado School of Medicine, Aurora, Colo., Vinh DC; Division of Infectious Diseases, Allergy & Clinical Immunology, Department of Medical Microbiology and Human Genetics, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada., Hagin D; Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Forbes Satter LR; The Texas Children's Hospital, Section of Immunology, Allergy and Retrovirology, The Baylor College of Medicine and the William T. Shearer Center for Human Immunobiology, Houston, Tex., Marsh RA; Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio., Chiang SCC; Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio., Willrich MAV; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn., Frazer-Abel AA; Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colo., Rider NL; The Texas Children's Hospital, Section of Immunology, Allergy and Retrovirology, The Baylor College of Medicine and the William T. Shearer Center for Human Immunobiology, Houston, Tex. Electronic address: nlrider@bcm.edu.
Jazyk:	angličtina
Zdroj:	The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2021 Sep; Vol. 9 (9), pp. 3293-3307.e6. Date of Electronic Publication: 2021 May 24.
DOI:	10.1016/j.jaip.2021.05.004
Abstrakt:	Knowledge related to the biology of inborn errors of immunity and associated laboratory testing methods continues to expand at a tremendous rate. Despite this, many patients with inborn errors of immunity suffer for prolonged periods of time before identification of their underlying condition, thereby delaying appropriate care. Understanding that test selection and optimal evaluation for patients with recurrent infections or unusual patterns of inflammation can be unclear, we present a document that distills relevant clinical features of immunologic disease due to inborn errors of immunity and related appropriate and available test options. This document is intended to serve the practicing clinical immunologist and, in turn, patients by describing best available test options for initial and expanded immunologic evaluations across the disease spectrum. Our goal is to demystify the process of evaluating patients with suspected immune dysfunction and to enable more rapid and accurate diagnosis of such individuals. (Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu