Short-term improvement of clinical parameters and microbial diversity in periodontitis patients following Indocyanine green-based antimicrobial photodynamic therapy: A randomized single-blind split-mouth cohort.

Autor: AlSarhan MA; Department of Periodontics & Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. Electronic address: malsarhan@ksu.edu.sa., Altammami MA; National Center for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia., Alaqeely RS; Department of Periodontics & Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia., AlEbdi A; Dental Internship Program, College of Dentistry, King Saud University, Riyadh, Saudi Arabia., Jasser RA; Department of Periodontics & Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia., Otaibi DA; Department of Periodontics & Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia., Oraini SA; Department of Periodontics & Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia., Habib SR; Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia., Alqahtani L; National Center for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia., Alduhaymi IS; National Center for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia., Alrabiah DK; National Center for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia., Alaradi M; National Center for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia., Alyamani EJ; National Center for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh 11461, Saudi Arabia.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2021 Sep; Vol. 35, pp. 102349. Date of Electronic Publication: 2021 May 24.
DOI: 10.1016/j.pdpdt.2021.102349
Abstrakt: Background: Indocyanine green-mediated photodynamic therapy is effective against chronic periodontitis. Here, we evaluated the efficiency of indocyanine green-based adjunctive antimicrobial photodynamic therapy in non-surgical treatment of chronic periodontitis patients.
Methods: Fifty-six periodontally involved teeth of 20 patients were treated with "scaling and root planing" (control group) or "scaling and root planing with indocyanine green-based (perio-green, 0.1 mg/ml) antimicrobial photodynamic therapy" (test group) using a split-mouth design. We performed clinical assessment of probing depth, gingival recession, clinical attachment loss, and other indices, while plaque samples were collected for microbiome analysis.
Results: At baseline, periodontal depth and clinical attachment loss were significantly higher in the test group (p < 0.05), and at 1-month post-treatment, we observed a significant favorable reduction of both periodontal depth and clinical attachment loss in test and control sites, with lower means maintained at 3 months (p = 0.01 and p = 0.000, respectively). Additionally, analysis of variance showed significant improvements in periodontal depth and clinical attachment loss in the indocyanine green-antimicrobial photodynamic therapy group (p = 0.001), although not for clinical attachment loss in controls (p = 0.102). Moreover, a significant reduction was observed in test sites for bleeding on probing and residual pocket post-therapy (p = 0.04 and p = 0.0001 respectively). Furthermore, microbiome analysis identified Porphyromonons gingivalis, Treponema, and Tannerella in all samples with favorable changes in test sites (p = 0.07).
Conclusion: We observed a significant reduction in periodontal clinical parameters (periodontal depth and clinical attachment loss) in chronic periodontitis patients treated with antimicrobial photodynamic therapy as an adjunctive procedure to conventional scaling and root planing. This improvement was associated with periodontal pathogen reduction and increase in the healthy subgingival microbiome.
(Copyright © 2021. Published by Elsevier B.V.)
Databáze: MEDLINE
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