Inflammation can increase hepcidin in HFE -hereditary hemochromatosis.

Autor: Moris W; Department of Internal Medicine, Gastroenterology and Clinical Geriatrics Zuyderland Medical Center Sittard-Geleen The Netherlands.; Division of Gastroenterology and Hepatology Department of Internal Medicine Maastricht University Medical Centre Maastricht The Netherlands.; School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Maastricht The Netherlands., Verhaegh PLM; Division of Gastroenterology and Hepatology Department of Internal Medicine Maastricht University Medical Centre Maastricht The Netherlands.; School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Maastricht The Netherlands., Masclee AAM; Division of Gastroenterology and Hepatology Department of Internal Medicine Maastricht University Medical Centre Maastricht The Netherlands.; School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Maastricht The Netherlands., Swinkels DW; Department of Laboratory Medicine (TML 830) Radboud University Medical Center Nijmegen The Netherlands.; Hepcidinanalysis.com Nijmegen The Netherlands., Laarakkers CM; Department of Laboratory Medicine (TML 830) Radboud University Medical Center Nijmegen The Netherlands.; Hepcidinanalysis.com Nijmegen The Netherlands., Koek GH; Division of Gastroenterology and Hepatology Department of Internal Medicine Maastricht University Medical Centre Maastricht The Netherlands.; School of Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Maastricht The Netherlands., van Deursen CTBM; Department of Internal Medicine, Gastroenterology and Clinical Geriatrics Zuyderland Medical Center Sittard-Geleen The Netherlands.; Division of Gastroenterology and Hepatology Department of Internal Medicine Maastricht University Medical Centre Maastricht The Netherlands.
Jazyk: angličtina
Zdroj: Clinical case reports [Clin Case Rep] 2021 May 20; Vol. 9 (5), pp. e04114. Date of Electronic Publication: 2021 May 20 (Print Publication: 2021).
DOI: 10.1002/ccr3.4114
Abstrakt: We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can be upregulated by inflammation, probably via the JAK/STAT3 pathway.
Competing Interests: Coby Laarakkers and Dorine Swinkels are employees of Radboudumc that via its Hepcidinanalysis.com initiative offers high‐quality hepcidin measurements to the scientific, medical, and pharmaceutical communities at a fee for service basis. Our study aim was purely scientific and no commercial factors or intentions were involved. We have paid for the hepcidin assays. The other auteurs have no conflicts of interest to declare.A. M. Masclee has received a consultancy fee from Allergan, Takeda, and Kyowa Kirin. A. M. Masclee has received a ZonMw (The Netherlands Organisation for Health Research and Development [Dutch government]), healthcare efficiency grant. A. M. Masclee has received an unrestricted research grant from Will Pharma SA and he has received research funding from Allergan and Grünenthal. A. M. Masclee has received funding from PENTAX Europe GmbH. All fundings/grants were received unrelated to the current study. The other authors have no financial relationships to disclose.
(© 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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