Health-related quality of life in adults with tetralogy of Fallot repair: a systematic review and meta-analysis.

Autor: Malik M; Department of Cardiothoracic Surgery, The Aga Khan University Hospital, Stadium Road, Karachi, 74800, Pakistan., Dawood ZS; Medical College, The Aga Khan University Hospital, Stadium Road, Karachi, 74800, Pakistan., Janjua M; Medical College, The Aga Khan University Hospital, Stadium Road, Karachi, 74800, Pakistan., Chauhan SSB; Medical College, The Aga Khan University Hospital, Stadium Road, Karachi, 74800, Pakistan., Ladak LA; School of Nursing and Midwifery, Department of Pediatrics and Child Health, The Aga Khan University, Stadium Road, Karachi, 74800, Pakistan. laila.ladak@aku.edu.; Susan Wakil School of Nursing and Midwifery, Sydney Nursing School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. laila.ladak@aku.edu.
Jazyk: angličtina
Zdroj: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation [Qual Life Res] 2021 Oct; Vol. 30 (10), pp. 2715-2725. Date of Electronic Publication: 2021 May 22.
DOI: 10.1007/s11136-021-02875-5
Abstrakt: Background: With the advancement in diagnostics and clinical management, patients with Tetralogy of Fallot (ToF) are surviving till adulthood. Hence, assessing the impact of ToF repair on health-related quality of life (HRQOL) of these patients is becoming increasingly important. The objective of this paper is to conduct a systematic review and meta-analysis of the HRQOL in patients who have undergone ToF repair.
Methods: A systematic search was conducted using PubMed, CINAHL, Medline and Web of Science databases. Studies that compared the HRQOL of adult patients (mean age ≥ 18 years) who had previously undergone ToF repair with healthy controls were included. Analysis was done via Revman V5.3 using a random effects model.
Results: The 16 studies (15 using SF-36) included in the meta-analysis, comprised 1818 patients and 50,265 healthy controls. There was a higher proportion of males (59%). The mean ages at surgery and at HRQOL assessment were 5.37 years and 30.3 years, respectively. We found that repaired ToF patients had a statistically significantly lower score in the physical component summary (SMD = - 0.92 CI = - 1.54, - 0.30) and physical functioning (SMD = - 0.27 CI = - 0.50, - 0.03) compared to healthy controls. However, these patients had statistically significantly higher scores in the bodily pain domain (SMD = 0.35 CI = 0.12, 0.58) and social functioning (SMD = 0.23 CI = 0.01, 0.46), while there was no significant difference in other domains.
Conclusion: Overall, physical domain of HRQOL was statistically significantly lower in repaired ToF patients compared to healthy controls. However, repaired ToF patients scored significantly higher on bodily pain and Social Functioning. There was additionally no difference in the HRQOL between the two groups in other domains of HRQOL.
(© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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