Rivaroxaban for the prevention of venous thromboembolism after radiofrequency ablation of saphenous veins concomitant with miniphlebectomy, sclerotherapy, or no treatment of varicose tributaries.
| Autor: | Murzina E; Hospital 'Neftyanik' Tyumen, Russian Federation., Lobastov K; Pirogov Russian National Research Medical University, Moscow, Russian Federation., Laberko L; Pirogov Russian National Research Medical University, Moscow, Russian Federation., Dvornikov A; Pirogov Russian National Research Medical University, Moscow, Russian Federation., Popov I; Tyumen State Medical University, Tyumen, Russian Federation. |
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| Jazyk: | angličtina |
| Zdroj: | Phlebology [Phlebology] 2021 Oct; Vol. 36 (9), pp. 741-751. Date of Electronic Publication: 2021 May 21. |
| DOI: | 10.1177/02683555211017336 |
| Abstrakt: | Objective: To assess the efficacy and safety of once-daily 10 mg rivaroxaban for venous thromboembolism prophylaxis after ClosureFast radiofrequency ablation (RFA) of saphenous veins. Method: The medical records of patients, who had a Caprini score of ≥3, underwent RFA, received prophylactic rivaroxaban for five days, and completed follow up at one month were reviewed for efficacy (a combination of endovenous heat-induced thrombosis [EHIT] grade of 2-4, any symptomatic or asymptomatic deep vein thrombosis [DVT], and symptomatic pulmonary embolism [PE]) and safety (a combination of major and clinically relevant non-major [CRNM] bleeding) outcomes. Results: The results of RFA for 248 great saphenous and 24 small saphenous veins with the concomitant miniphlebectomy (63.8%) and sclerotherapy (16.5%) were analyzed. The primary efficacy outcome occurred in 5 of 218 (2.3%; 95%CI, 1.0-5.3%) patients: three EHITs and two symptomatic DVTs. The CRNM bleeding was reported in two patients (0.9%; 95% CI, 0.2-3.3%). No difference was observed in comparison with 79 similar patients who received 40 mg of subcutaneous enoxaparin during the same time period. Conclusion: Once-daily 10 mg rivaroxaban is suitable for VTE prophylaxis after RFA of saphenous veins. |
| Databáze: | MEDLINE |
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