Diabetic nephropathy: A twisted thread to unravel.

Autor: Dagar N; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Hajipur), Export Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur 844102, Bihar, India., Das P; National Institute of Pharmaceutical Education and Research (NIPER)-Kolkata, Chunilal Bhawan, 168 Maniktala Main Road, Kolkata 700054, West Bengal, India., Bisht P; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Hajipur), Export Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur 844102, Bihar, India., Taraphdar AK; Institute of Post Graduate Ayurvedic Education and Research, 294/3/1, A.P.C. Road, Kolkata 700009, West Bengal, India., Velayutham R; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Hajipur), Export Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur 844102, Bihar, India; National Institute of Pharmaceutical Education and Research (NIPER)-Kolkata, Chunilal Bhawan, 168 Maniktala Main Road, Kolkata 700054, West Bengal, India., Arumugam S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Hajipur), Export Promotion Industrial Park (EPIP), Zandaha Road, NH322, Hajipur 844102, Bihar, India; National Institute of Pharmaceutical Education and Research (NIPER)-Kolkata, Chunilal Bhawan, 168 Maniktala Main Road, Kolkata 700054, West Bengal, India. Electronic address: somasundaram.niperk@nic.in.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119635. Date of Electronic Publication: 2021 May 17.
DOI: 10.1016/j.lfs.2021.119635
Abstrakt: Diabetic nephropathy (DN), a persistent microvascular problem of diabetes mellitus is described as an elevated level of albumin excretion in urine and impaired renal activity. The morbidity and mortality of type-1 diabetics and type-2 diabetics due to end stage renal disease is also a result of the increased prevalence of DN. DN typically occurs as a consequence of an association among metabolic and hemodynamic variables, activating specific pathways leading to renal injury. According to current interventions, intensive glucose regulation decreases the threat of DN incidence and growth, and also suppressing the renin-angiotensin system (RAS) is a significant goal for hemodynamic and metabolism-related deformities in DN. However, the pathogenesis of DN is multifactorial so novel approaches other than glucose and blood pressure control are required for treatment. This review briefly summarizes the reported pathogenesis of DN, current interventions for its treatment, and possible novel interventions to unweave the thread of DN.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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