Reproductive Hormone Concentrations and Associated Anatomical Responses: Does Soy Formula Affect Minipuberty in Boys?

Autor:	Chin HB; Department of Global and Community Health, George Mason University, Fairfax, VA 22030, USA., Kelly A; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.; Department of Pediatrics, Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Adgent MA; Department of Health Policy, Vanderbilt University Medical Center, Nashville, TN 37203, USA., Patchel SA; Westat, Inc., Durham, NC 27703, United States., James K; Social & Scientific Systems, Inc., Durham, NC 27703, USA., Vesper HW; Clinical Standardization Programs, CDC, Atlanta, GA 30341, USA., Botelho JC; Division of Laboratory Sciences, National Center for Environmental Health, CDC, Atlanta, GA 30341, USA., Chandler DW; Endocrine Sciences, LabCorp, Calabasas Hills, CA 91301, USA., Zemel BS; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Schall JI; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Ford EG; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Darge K; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.; Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Stallings VA; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Baird DD; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA., Rogan WJ; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA., Umbach DM; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2021 Aug 18; Vol. 106 (9), pp. 2635-2645.
DOI:	10.1210/clinem/dgab354
Abstrakt:	Context: Soy formula feeding is common in infancy and is a source of high exposure to phytoestrogens, documented to influence vaginal cytology in female infants. Its influence on minipuberty in males has not been established. Objective: To assess the association between infant feeding practice and longitudinally measured reproductive hormones and hormone-responsive tissues in infant boys. Methods: The Infant Feeding and Early Development study was a prospective cohort of maternal-infant dyads requiring exclusive soy formula, cow milk formula, or breast milk feeding during study follow-up. In the 147 infant boy participants, serum testosterone, luteinizing hormone, stretched penile length, anogenital distance, and testis volume were longitudinally assessed from birth to 28 weeks. We examined feeding-group differences in age trajectories for these outcomes using mixed-effects regression splines. Results: Median serum testosterone was at pubertal levels at 2 weeks (176 ng/dL [quartiles: 124, 232]) and remained in this range until 12 weeks in all feeding groups. We did not observe differences in trajectories of hormone concentrations or anatomical measures between boys fed soy formula (n = 55) and boys fed cow milk formula (n = 54). Compared with breastfed boys (n = 38), soy formula-fed boys had a more rapid increase in penile length (P = .004) and slower initial lengthening of anogenital distance (P = .03), but no differences in hormone trajectories. Conclusion: Reproductive hormone concentrations and anatomical responses followed similar trajectories in soy and cow milk formula-fed infant boys. Our findings suggest that these measures of early male reproductive development do not respond to phytoestrogen exposure during infancy. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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