Simultaneous assessment of coronary stenosis relevance with automated computed tomography angiography and intravascular ultrasound analyses and fractional flow reserve.

Autor:	Blanco PJ; Department of Mathematical and Computational Methods, National Laboratory for Scientific Computing.; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, Petrópolis, Brazil., Bulant CA; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, Petrópolis, Brazil.; Department of Computer Systems, National Scientific and Technical Research Council (CONICET) and National University of the Center, Tandil, Argentina., Bezerra CG; Department of Interventional Cardiology, Heart Institute (InCor) and the University of São Paulo Medical School, São Paulo.; Hospital Ana Nery, Bahia., Lemos PA; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, Petrópolis, Brazil.; Department of Interventional Cardiology, Heart Institute (InCor) and the University of São Paulo Medical School, São Paulo.; Department of Interventional Cardiology, Hospital Israelita Albert Einstein, São Paulo, Brazil., García-García HM; MedStar Washington Hospital Center, Interventional Cardiology Department and Georgetown University School of Medicine, Washington, DC, USA.
Jazyk:	angličtina
Zdroj:	Coronary artery disease [Coron Artery Dis] 2022 Jan 01; Vol. 31 (1), pp. 25-30.
DOI:	10.1097/MCA.0000000000001044
Abstrakt:	Objectives: To assess the diagnostic performance of computed tomography angiography (CTA) and intravascular ultrasound (IVUS) derived minimum lumen areas (MLA) from the same lesions that correspond to an FFR ≤0.80. Methods and Results: A total of 24 patients (33 arteries) were collected retrospectively according to the following inclusion criteria: presence of a CTA diagnostic followed by an IVUS and FFR percutaneous coronary procedures. CTA and IVUS lumen contours were automatically performed using previously validated methods.The correlation between CTA and IVUS for the MLA was r = 0.45. In terms of MLA, the mean difference between CTA and IVUS was 0.81 mm2. Of note, a much smaller CTA-derived MLA (2.10 mm2) was found to be related to significant FFR lesions compared to that of the MLA derived from IVUS (3.19 mm2). The area under the curve, accuracy, sensitivity and specificity for this CTA-derived MLA were 0.80, 0.76, 0.50 and 0.87, respectively, while these values for IVUS-derived MLA were 0.87, 0.85, 0.80 and 0.87. Conclusions: Computed tomography angiography and intravascular ultrasound-derived minimum lumen areas have moderate diagnostic efficiency, albeit slightly better for IVUS, in identifying hemodynamically severe coronary stenoses. The utility of MLA, automatically derived from either CTA or IVUS as an alternative to FFR to guide the decision to revascularize, should be tested clinically. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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