Inflammatory markers in acne vulgaris: Saliva as a novel diagnostic fluid.

Autor: Monib KME; Dermatology and Andrology Department, Faculty of Medicine, Benha University, Benha, Egypt., El-Fallah AA; Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt., Salem RM; Dermatology and Andrology Department, Faculty of Medicine, Benha University, Benha, Egypt.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2022 Mar; Vol. 21 (3), pp. 1280-1285. Date of Electronic Publication: 2021 Jun 02.
DOI: 10.1111/jocd.14236
Abstrakt: Background: Despite the wide use of saliva-based measurements in inflammatory, autoimmune and neoplastic conditions, its use in dermatology is still limited.
Aims: The aims of this study were to assess the serum and salivary levels of interleukin-1 beta (IL-1β) and C-reactive protein (CRP) in patients with acne vulgaris.
Patients/methods: The study included 84 moderate-to-severe acne vulgaris patients, in addition to 105 healthy control subjects. Serum and salivary levels of CRP and IL-1β were estimated using enzyme-linked immunosorbent assay (ELISA) technique.
Results: Using T-test, the serum and salivary levels of both CRP and IL-1β in the patients were significantly higher than the measured levels in the control subjects (p < 0.001). Using Pearson correlation coefficient, serum and salivary CRP and serum IL-1β levels showed significantly positive correlation with GAGS scores (p < 0.001). The levels of IL-1β in saliva did not show significant correlation with GAGS scores or with serum and salivary CRP.
Conclusions: The current study supports the emerging role of saliva as a valid noninvasive tool for monitoring inflammation and as a reliable and stress-free tool to evaluate cytokines and other inflammatory marker levels in acne vulgaris.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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