[Significance of platelets in inflammatory and thrombotic reactions in the elderly.]

Autor:	Osadchuk AM; Samara State Medical University, 89 Chapaevskaya str., Samara 443099, Russian Federation, e-mail: zolotovskay@list.ru., Davydkin IL; Samara State Medical University, 89 Chapaevskaya str., Samara 443099, Russian Federation, e-mail: zolotovskay@list.ru., Zolotovskaia IA; Samara State Medical University, 89 Chapaevskaya str., Samara 443099, Russian Federation, e-mail: zolotovskay@list.ru.
Jazyk:	ruština
Zdroj:	Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2021; Vol. 34 (1), pp. 76-83.
Abstrakt:	The development of thrombotic reactions that lead to undesirable clinical consequences in the elderly is known in many diseases, including pathology of the cardiovascular system. Today, data on the severity of changes in the hemostatic system in patients with a new coronavirus infection (COVID-19) and the study of platelet and plasma levels are being accumulated. In order to understand some of the mechanisms associated with platelet pathology, we present a review that summarizes information about the pathophysiological reactions of platelets in the conditions of their aging and possible mechanisms of their pathological aggregation. Perhaps the presented fundamental and clinical data will be of interest to a wide audience of specialists to discuss early antiplatelet therapy and its justification not only in patients with cardiovascular diseases, but also with COVID-19.
Databáze:	MEDLINE
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