Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene.

Autor:	Ma SL; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, China., Chen LH; Centre for PanorOmic Sciences - Genomics and Bioinformatics Cores, The University of Hong Kong, Hong Kong, China.; Department of Psychology, The Chinese University of Hong Kong, Hong Kong, China., Lee CC; Kwai Chung Hospital, Hospital Authority, Hong Kong, China., Lai KYC; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, China., Hung SF; Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, China., Tang CP; Kwai Chung Hospital, Hospital Authority, Hong Kong, China., Ho TP; Department of Psychiatry, The University of Hong Kong, Hong Kong, China., Shea C; Alice Ho Miu Ling Nethersole Hospital, Hospital Authority, Hong Kong, China., Mo F; Alice Ho Miu Ling Nethersole Hospital, Hospital Authority, Hong Kong, China., Mak TSH; Centre for PanorOmic Sciences - Genomics and Bioinformatics Cores, The University of Hong Kong, Hong Kong, China., Sham PC; Centre for PanorOmic Sciences - Genomics and Bioinformatics Cores, The University of Hong Kong, Hong Kong, China.; Department of Psychiatry, The University of Hong Kong, Hong Kong, China., Leung PWL; Department of Psychology, The Chinese University of Hong Kong, Hong Kong, China.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2021 Apr 27; Vol. 15, pp. 649588. Date of Electronic Publication: 2021 Apr 27 (Print Publication: 2021).
DOI:	10.3389/fnins.2021.649588
Abstrakt:	Background: Recent findings indicated a high comorbidity between attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), as well as shared genetic influences on them. The latter might contribute at least partly to the former clinical scenario. This study aimed at investigating whether SHANK genes were potential pleiotropic genes to the two said disorders, underlying their genetic overlap. Methods: This study recruited 298 boys with ADHD (including 256 family trios of 1 ADHD boy and his 2 biological parents), 134 boys with ASD, 109 boys with both ADHD and ASD, and 232 typically developing boys as community controls. They were aged between 6 and 11 years old. Results: There was no significant difference in allele frequency of a number of single nucleotide polymorphisms (SNPs) in SHANK2 / SHANK3 between the three clinical groups (ADHD, ASD, and ADHD + ASD) and between the two control groups (community controls and pseudo-controls), respectively. The three clinical groups and the two control groups were thus, respectively, combined. A comparison between the two aggregated samples identified significant evidence of disease association for three SHANK2 SNPs with both ADHD and ASD, even after multiple testing correction: rs11236616 ( OR = 0.762, permuted p = 0.0376), rs7106631 ( OR = 0.720, permuted p = 0.0034), and rs9888288 ( OR = 0.770, permuted p = 0.0407). Comparisons among individual groups pointed to a similar trend of findings. Conclusion: SHANK2 could be considered a potential pleiotropic gene underlying the genetic overlap between ADHD and ASD. This might contribute partly to their high comorbidity in the afflicted children. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Ma, Chen, Lee, Lai, Hung, Tang, Ho, Shea, Mo, Mak, Sham and Leung.)
Databáze:	MEDLINE
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