| Autor: |
Summers RLS; University of Minnesota, Minneapolis, MN, USA., Rafferty MR; Northwestern University, Chicago, IL, USA., Howell MJ; University of Minnesota, Minneapolis, MN, USA., MacKinnon CD; University of Minnesota, Minneapolis, MN, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Neurorehabilitation and neural repair [Neurorehabil Neural Repair] 2021 Jul; Vol. 35 (7), pp. 611-621. Date of Electronic Publication: 2021 May 12. |
| DOI: |
10.1177/15459683211011238 |
| Abstrakt: |
Parkinson disease (PD) and other related diseases with α-synuclein pathology are associated with a long prodromal or preclinical stage of disease. Predictive models based on diagnosis of idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) make it possible to identify people in the prodromal stage of synucleinopathy who have a high probability of future disease and provide an opportunity to implement neuroprotective therapies. However, rehabilitation providers may be unaware of iRBD and the motor abnormalities that indicate early motor system dysfunction related to α-synuclein pathology. Furthermore, there is no existing rehabilitation framework to guide early interventions for people with iRBD. The purpose of this work is to (1) review extrapyramidal signs of motor system dysfunction in people with iRBD and (2) propose a framework for early protective or preventive therapies in prodromal synucleinopathy using iRBD as a predictive marker. Longitudinal and cross-sectional studies indicate that the earliest emerging motor deficits in iRBD are bradykinesia, deficits performing activities of daily living, and abnormalities in speech, gait, and posture. These deficits may emerge up to 12 years before a diagnosis of synucleinopathy. The proposed rehabilitation framework for iRBD includes early exercise-based interventions of aerobic exercise, progressive resistance training, and multimodal exercise with rehabilitation consultations to address exercise prescription, progression, and monitoring. This rehabilitation framework may be used to implement neuroprotective, multidisciplinary, and proactive clinical care in people with a high likelihood of conversion to PD, dementia with Lewy bodies, or multiple systems atrophy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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