Circuit organization of the rodent medial prefrontal cortex.

Autor: Anastasiades PG; Department of Translational Health Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK., Carter AG; Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA. Electronic address: adam.carter@nyu.edu.
Jazyk: angličtina
Zdroj: Trends in neurosciences [Trends Neurosci] 2021 Jul; Vol. 44 (7), pp. 550-563. Date of Electronic Publication: 2021 May 07.
DOI: 10.1016/j.tins.2021.03.006
Abstrakt: The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous variety of projection neurons and interneurons. These cells are engaged by long-range inputs from other brain regions involved in cognition, motivation, and emotion. They also communicate in the local network via specific connections between excitatory and inhibitory cells. In this review, we describe the cellular diversity of the rodent mPFC, the impact of long-range afferents, and the specificity of local microcircuits. We highlight similarities with and differences between other cortical areas, illustrating how the circuit organization of the mPFC may give rise to its unique functional roles.
Competing Interests: Declaration of interests The authors declare no interests in relation to this work.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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