| Autor: |
Weschenfelder C; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia do Rio Grande do Sul (IC/FUC), 395 Princesa Isabel Avenue, 90040-371 Porto Alegre, Rio Grande do Sul, Brazil., Gottschall CBA; Graduate Program in Nutrition Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), 245 Sarmento Leite Street, 90050-170 Porto Alegre, Rio Grande do Sul, Brazil., Markoski MM; Graduate Program in Biosciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), 245 Sarmento Leite Street, 90050-170 Porto Alegre, Rio Grande do Sul, Brazil., Portal VL; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia do Rio Grande do Sul (IC/FUC), 395 Princesa Isabel Avenue, 90040-371 Porto Alegre, Rio Grande do Sul, Brazil., Quadros AS; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia do Rio Grande do Sul (IC/FUC), 395 Princesa Isabel Avenue, 90040-371 Porto Alegre, Rio Grande do Sul, Brazil., Bersch-Ferreira ÂC; HCor Research Institute, Hospital do Coração (IP-HCor). 250 Abílio Soares Street, 04004-050 São Paulo, SP, Brazil., Marcadenti A; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia do Rio Grande do Sul (IC/FUC), 395 Princesa Isabel Avenue, 90040-371 Porto Alegre, Rio Grande do Sul, Brazil.; HCor Research Institute, Hospital do Coração (IP-HCor). 250 Abílio Soares Street, 04004-050 São Paulo, SP, Brazil. |
| Abstrakt: |
The consumption of nuts and extra-virgin olive oil has been associated with suppression of inflammatory pathways that contribute to atherosclerosis, but its role on the modulation of the inflammatory profile in patients with established coronary artery disease (CAD) is unclear. The aim of this study was to evaluate the effects of adding pecan nuts or extra-virgin olive oil to a healthy diet on inflammatory markers in patients with stable CAD. In this randomised clinical trial, 204 patients were enrolled to three study groups: sixty seven to control group (CG: healthy diet), sixty eight to pecan nuts group (PNG: 30 g/d of pecans + healthy diet) and sixty nine to extra-virgin olive oil group (OOG: 30 ml/d of extra-virgin olive oil + healthy diet). High-sensitivity C-reactive protein (hs-CRP, in mg/l), fibrinogen (mg/dl), IL 2, 4, 6, 10 (pg/ml) and interferon-γ (IFN-γ, in pg/ml), IL-6/IL-10, IL-2/IL-4 and IFN-/γIL-4 ratios were evaluated at baseline and after the follow-up (12 weeks). As main results, after adjustment for sex, statin used and relative body weight variation, there were no differences between groups regarding inflammatory markers at the end of the study. IL-6 levels (primary outcome) were reduced in 12 weeks when compared with baseline in all study groups (CG: difference: -0·593 (se = 0·159) pg/dL; PNG: difference: -0·335 (se = 0·143) pg/dl; OOG: IL-6 difference: -0·325 (se = 0·143) pg/dl). In conclusion, there was no significant effect of including pecan nuts or extra virgin olive oil to a healthy diet on inflammatory markers in individuals with CAD. |
