Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline.

Autor:	Hansen N; Department of Psychiatry and Psychotherapy, Göttingen, Germany.; Laboratory of Systems Neuroscience and Imaging in Psychiatry, University Medical Center Göttingen, Göttingen, Germany., Singh A; Department of Psychiatry and Psychotherapy, Göttingen, Germany.; Laboratory of Systems Neuroscience and Imaging in Psychiatry, University Medical Center Göttingen, Göttingen, Germany., Bartels C; Department of Psychiatry and Psychotherapy, Göttingen, Germany., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Buerger K; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Cetindag AC; Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Dobisch L; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Dechent P; MR-Research in Neurology and Psychiatry, University Medical Center Göttingen, Göttingen, Germany., Ertl-Wagner BB; Institute for Clinical Radiology, Ludwig-Maximilians-University, Munich, Germany., Fliessbach K; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Haynes JD; Bernstein Center for Computational Neuroscience, Charité-Universitätsmedizin, Berlin, Germany., Heneka MT; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Janowitz D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Kilimann I; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Laske C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Metzger CD; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany.; Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany., Munk MH; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Peters O; Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Berlin, Germany., Roy N; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Scheffler K; Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Spruth EJ; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Berlin, Germany., Teipel S; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Tscheuschler M; Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany., Vukovich R; Department of Psychiatry and Psychotherapy, Göttingen, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Neurosciences and Signaling Group, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Duezel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany., Jessen F; Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Köln, Germany., Goya-Maldonado R; Department of Psychiatry and Psychotherapy, Göttingen, Germany.; Laboratory of Systems Neuroscience and Imaging in Psychiatry, University Medical Center Göttingen, Göttingen, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2021 Apr 21; Vol. 13, pp. 626974. Date of Electronic Publication: 2021 Apr 21 (Print Publication: 2021).
DOI:	10.3389/fnagi.2021.626974
Abstrakt:	Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases. Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups. Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode. Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Hansen, Singh, Bartels, Brosseron, Buerger, Cetindag, Dobisch, Dechent, Ertl-Wagner, Fliessbach, Haynes, Heneka, Janowitz, Kilimann, Laske, Metzger, Munk, Peters, Priller, Roy, Scheffler, Schneider, Spottke, Spruth, Teipel, Tscheuschler, Vukovich, Wiltfang, Duezel, Jessen and Goya-Maldonado.)
Databáze:	MEDLINE
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