Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential.

Autor:	Mangalea MR; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Paez-Espino D; Ancilia Biosciences, New York, NY 19808, USA., Kieft K; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53715, USA., Chatterjee A; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Chriswell ME; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Seifert JA; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Feser ML; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Demoruelle MK; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Sakatos A; Ancilia Biosciences, New York, NY 19808, USA., Anantharaman K; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53715, USA., Deane KD; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Kuhn KA; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Holers VM; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Duerkop BA; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: breck.duerkop@cuanschutz.edu.
Jazyk:	angličtina
Zdroj:	Cell host & microbe [Cell Host Microbe] 2021 May 12; Vol. 29 (5), pp. 726-739.e5. Date of Electronic Publication: 2021 May 05.
DOI:	10.1016/j.chom.2021.03.020
Abstrakt:	Rheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive individuals by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked to the intestinal microbiota, yet the association of microbes with CCP serology and their contribution to RA is unclear. We describe intestinal phage communities of individuals at risk for developing RA, with or without anti-CCP antibodies, whose first-degree relatives have been diagnosed with RA. We show that at-risk individuals harbor intestinal phage compositions that diverge based on CCP serology, are dominated by Streptococcaceae, Bacteroidaceae, and Lachnospiraceae phages, and may originate from disparate ecosystems. These phages encode unique repertoires of auxiliary metabolic genes, which associate with anti-CCP status, suggesting that these phages directly influence the metabolic and immunomodulatory capability of the microbiota. This work sets the stage for the use of phages as preclinical biomarkers and provides insight into a possible microbial-based causation of RA disease development. Competing Interests: Declaration of interests D.P.-E is a co-founder/employee of Ancilia Biosciences. A.S. is the founder/employee of Ancilia Biosciences. B.A.D. is a co-founder and shareholder of Ancilia Biosciences. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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