Clinical Features of Patients with Home Isolation Sars-Cov-2 Infection: A Multicenter Retrospective Study in Southern Italy.

Autor: Pisaturo M; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania 'L. Vanvitelli', 80100 Naples, Italy.; Third Infectious Diseases Unit, AORN dei Colli, P.O. Cotugno, 34105 Naples, Italy., De Angelis G; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania 'L. Vanvitelli', 80100 Naples, Italy., Maggi P; Infectious Diseases Unit, A.O. S Anna e S Sebastiano, 23868 Caserta, Italy., Sangiovanni V; Third Infectious Diseases Unit, AORN dei Colli, P.O. Cotugno, 34105 Naples, Italy., Numis FG; Emergency Unit, PO Santa Maria delle Grazie, 80078 Pozzuoli, Italy., Gentile I; Infectious Disease Unit, University Federico II, 34105 Naples, Italy., Masullo A; Infectious Disease Unit, A.O. San Giovanni di Dio e Ruggi D'Aragona, 84100 Salerno, Italy., Rescigno C; First Infectious Disease Unit, AORN dei Coli, PO Cotugno, 34105 Naples, Italy., Calabria G; IX Infectious Disease Unit, AORN dei Coli, PO Cotugno, 34105 Naples, Italy., Salomone Megna A; Infectious Disease Unit, A.O. San Pio, PO Rummo, 82100 Benevento, Italy., Gambardella M; Infectious Disease Unit, PO S. Luca, Vallo della Lucania, ASL, 84100 Salerno, Italy., Manzillo E; VIII Infectious Disease Unit, AORN dei Coli, PO Cotugno, 34105 Naples, Italy., Giolitto G; Infectious Disease Unit, Ospedale Maria S.S. Addolorata di Eboli, ASL, 84100 Salerno, Italy., Rossomando A; IV Infectious Disease Unit, AORN dei Coli, PO Cotugno, 34105 Naples, Italy., Buonomo AR; Infectious Disease Unit, University Federico II, 34105 Naples, Italy., Macera M; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania 'L. Vanvitelli', 80100 Naples, Italy., Messina V; Infectious Diseases Unit, A.O. S Anna e S Sebastiano, 23868 Caserta, Italy., Pagano A; Emergency Unit, PO Santa Maria delle Grazie, 80078 Pozzuoli, Italy., Pisapia R; First Infectious Disease Unit, AORN dei Coli, PO Cotugno, 34105 Naples, Italy., Farella N; IX Infectious Disease Unit, AORN dei Coli, PO Cotugno, 34105 Naples, Italy., Bosso G; Emergency Unit, PO Santa Maria delle Grazie, 80078 Pozzuoli, Italy., Coppola N; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania 'L. Vanvitelli', 80100 Naples, Italy.; Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania Luigi Vanvitelli, Naples, Via L. Armanni 5, 80131 Naples, Italy., Group C
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2021 Apr 16; Vol. 11 (4). Date of Electronic Publication: 2021 Apr 16.
DOI: 10.3390/life11040347
Abstrakt: To describe epidemiological and clinical features of patients confirmed as having SARS-CoV-2 infection and managed in isolation at home. We performed a multicenter retrospective study enrolling all SARS-CoV-2-positive adults evaluated from 28 February to 31 May 2020 at one of nine COVID-19 Units in southern Italy: we included patients receiving care at home and those admitted to hospital. We defined patients with not-severe disease if they were asymptomatic or experienced a mild infection that did not need oxygen (O 2 ) therapy and those with a severe infection if hospitalized and required O 2 therapy. We enrolled 415 patients with SARS-CoV-2 infection: 77 were managed in isolation at home, 338 required hospital management. The 77 patients in home isolation were less frequently male than hospitalized patients (55% vs. 64%; <0.01) and were younger (median age 45 years (IQR:19) vs. 62 (IQR 22); p < 0.01), had a lower Charlson comorbidity index (median 0 (IQR2) vs. 6 (IQR 3); p < 0.01), and included fewer subjects with an underlying chronic disease (36% vs. 59%; p < 0.01). According to a binomial logistic regression analysis, a younger age (OR: 0.96 (95% IC: 0.94-0.98), p < 0.01) and a low Charlson comorbidity index (OR: 0.66 (95% IC: 0.54-0.83); p < 0.01) were independent factors associated with at-home management. The identification of subjects with SARS-CoV-2 infection who could be managed in home isolation is useful in clinical practice. A younger age and no comorbidities were identified as factors independently associated with home management.
Databáze: MEDLINE
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