Malignant Phyllodes Tumor of the Breast: A Practice Review.

Autor: Fede ÂBS; Department of Medical Oncology, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Pereira Souza R; Department of Medical Oncology, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Doi M; Department of Breast Surgery, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., De Brot M; Department of Anatomic Pathology A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Aparecida Bueno de Toledo Osorio C; Department of Anatomic Pathology A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Rocha Melo Gondim G; Department of Radiation Oncology, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Casali-da-Rocha JC; Department of Oncogenetics, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Jbili R; Department of Oncogenetics, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Bitencourt AGV; Department of Imaging, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Alves de Souza J; Department of Imaging, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Caparica Bitton R; Institut Jules Bordet, Université Libre de Bruxelles (U.L.B.), 1050 Brussels, Belgium., Baroni Alves Makdissi F; Department of Breast Surgery, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Moraes Sanches S; Department of Medical Oncology, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil.
Jazyk: angličtina
Zdroj: Clinics and practice [Clin Pract] 2021 Apr 06; Vol. 11 (2), pp. 205-215. Date of Electronic Publication: 2021 Apr 06.
DOI: 10.3390/clinpract11020030
Abstrakt: Introduction: Phyllodes tumor (PT) of the breast, particularly malignant phyllodes tumor (mPT), is a rare fibroepithelial neoplasm. A complex diagnosis is based on pathologic, radiologic, and clinical findings, with controversies about what is the best therapeutic strategy.
Objective: Our objective was to provide an overview of the clinical, pathologic, and therapeutic aspects of this rare tumor.
Conclusions: mPT is a rare presentation of breast cancer and a challenge in clinical practice. A multidisciplinary approach should take into account some aspects like pathogenic mutations and hereditary syndromes. Oncologic surgery is the fundamental approach, and the use of adjuvant therapies is still controversial due to the lack of clinical trials. Treatment recommendations should be individualized according to patient risk and preferences. Prospective studies are fundamental to clarifying the best treatment for these tumors.
Databáze: MEDLINE
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