Left-Right Side-Specific Neuropeptide Mechanism Mediates Contralateral Responses to a Unilateral Brain Injury.

Autor:	Watanabe H; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, 751 24., Nosova O; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, 751 24., Sarkisyan D; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, 751 24., Storm Andersen M; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark, 5230., Carvalho L; Departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto, Instituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, Porto, Portugal, 4200-135., Galatenko V; Faculty of Mechanics and Mathematics, Lomonosov Moscow State University, Moscow, Russia, 119991., Bazov I; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, 751 24., Lukoyanov N; Departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto, Instituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, Porto, Portugal, 4200-135.; Medibrain, Vila do Conde, Porto, Portugal, 4480-807.; Brain Research Institute, Porto, Portugal, 4200-135., Maia GH; Medibrain, Vila do Conde, Porto, Portugal, 4480-807.; Brain Research Institute, Porto, Portugal, 4200-135.; Departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto, Instituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, Porto, Portugal, 4200-135., Hallberg M; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, 751 24., Zhang M; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark, 5230.; Neuronano Research Center, Department of Experimental Medical Science, Lund University, Lund, Sweden, 223 81., Schouenborg J; Neuronano Research Center, Department of Experimental Medical Science, Lund University, Lund, Sweden, 223 81., Bakalkin G; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, 751 24 georgy.bakalkin@farmbio.uu.se.
Jazyk:	angličtina
Zdroj:	ENeuro [eNeuro] 2021 May 25; Vol. 8 (3). Date of Electronic Publication: 2021 May 25 (Print Publication: 2021).
DOI:	10.1523/ENEURO.0548-20.2021
Abstrakt:	Neuropeptides are implicated in control of lateralized processes in the brain. A unilateral brain injury (UBI) causes the contralesional sensorimotor deficits. To examine whether opioid neuropeptides mediate UBI induced asymmetric processes we compared effects of opioid antagonists on the contralesional and ipsilesional hindlimb responses to the left-sided and right-sided injury in rats. UBI induced hindlimb postural asymmetry (HL-PA) with the contralesional hindlimb flexion, and activated contralesional withdrawal reflex of extensor digitorum longus (EDL) evoked by electrical stimulation and recorded with EMG technique. No effects on the interossei (Int) and peroneaus longus (PL) were evident. The general opioid antagonist naloxone blocked postural effects, did not change EDL asymmetry while uncovered cryptic asymmetry in the PL and Int reflexes induced by UBI. Thus, the spinal opioid system may either mediate or counteract the injury effects. Strikingly, effects of selective opioid antagonists were the injury side-specific. The μ-antagonist β-funaltrexamine (FNA) and κ-antagonist nor-binaltorphimine (BNI) reduced postural asymmetry after the right but not left UBI. In contrast, the δ-antagonist naltrindole (NTI) inhibited HL-PA after the left but not right-side brain injury. The opioid gene expression and opioid peptides were lateralized in the lumbar spinal cord, and coordination between expression of the opioid and neuroplasticity-related genes was impaired by UBI that together may underlie the side-specific effects of the antagonists. We suggest that mirror-symmetric neural circuits that mediate effects of left and right brain injury on the contralesional hindlimbs are differentially controlled by the lateralized opioid system. (Copyright © 2021 Watanabe et al.)
Databáze:	MEDLINE
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