A Catheter-Related Bloodstream Infection by Brevibacterium casei in a Child with Acute Myeloid Leukemia: Case Report and Literature Review.

Autor: Ochi F; Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan., Tauchi H; Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan., Moritani K; Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan., Murakami S; Clinical Laboratory Division, Ehime University Hospital, Toon, Ehime 791-0295, Japan., Miyamoto H; Clinical Laboratory Division, Ehime University Hospital, Toon, Ehime 791-0295, Japan., Ueda M; Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan., Nagai K; Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan., Eguchi-Ishimae M; Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan., Eguchi M; Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.
Jazyk: angličtina
Zdroj: Case reports in pediatrics [Case Rep Pediatr] 2021 Apr 09; Vol. 2021, pp. 6691569. Date of Electronic Publication: 2021 Apr 09 (Print Publication: 2021).
DOI: 10.1155/2021/6691569
Abstrakt: The most common organisms isolated from pediatric catheter-related bloodstream infections (CRBSIs) are Gram-positive cocci, such as coagulase-negative staphylococci and Staphylococcus aureus . There are few formal reports of Brevibacterium casei infection and even fewer reports of CRBSI due to this Gram-positive rod. Here we report the first case of CRBSI due to B. casei in an 8-year-old girl with acute myeloid leukemia in Japan. The isolate exhibited decreased susceptibility to ß -lactam antibiotics. Antimicrobial therapy with meropenem and vancomycin, in addition to the removal of central venous catheter line, consequently led to a significant clinical improvement of the patient's symptoms. A literature review found available clinical courses in 16 cases (4 pediatric cases including our case) of B. casei infection. Our case and those in literature suggested that B. casei infection often occurs in patients with indwelling central venous catheters; the literature review further suggested that removal of central venous catheters is required in most cases. Special attention should be paid to the detection of opportunistic infections due to Brevibacterium spp. in immunocompromized children who are using a central venous catheter.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2021 Fumihiro Ochi et al.)
Databáze: MEDLINE
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