Seroprevalence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Kenya.

Autor:	Etyang AO; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Lucinde R; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Karanja H; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Kalu C; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Mugo D; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Nyagwange J; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Gitonga J; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Tuju J; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Wanjiku P; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Karani A; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Mutua S; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Maroko H; KEMRI Center for Infectious and Parasitic Diseases Control Research, Alupe, Kenya., Nzomo E; Kilifi County Hospital, Kilifi, Kenya., Maitha E; Department of Health, Kilifi County, Kenya., Kamuri E; Kenyatta National Hospital, Nairobi, Kenya., Kaugiria T; Kenyatta National Hospital, Nairobi, Kenya., Weru J; Kenyatta National Hospital, Nairobi, Kenya., Ochola LB; Alupe Sub-County Hospital, Busia, Kenya., Kilimo N; Institute of Primate Research, Nairobi, Kenya., Charo S; Kocholia Sub-County Hospital, Busia, Kenya., Emukule N; Busia County Referral Hospital, Busia, Kenya., Moracha W; Department of Health, Busia County, Busia, Kenya., Mukabi D; Department of Health, Busia County, Busia, Kenya., Okuku R; Department of Health, Busia County, Busia, Kenya., Ogutu M; Department of Health, Busia County, Busia, Kenya., Angujo B; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Otiende M; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Bottomley C; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Otieno E; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Ndwiga L; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Nyaguara A; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Voller S; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Agoti CN; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Nokes DJ; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Ochola-Oyier LI; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Aman R; Ministry of Health, Government of Kenya, Nairobi, Kenya., Amoth P; Ministry of Health, Government of Kenya, Nairobi, Kenya., Mwangangi M; Ministry of Health, Government of Kenya, Nairobi, Kenya., Kasera K; Ministry of Health, Government of Kenya, Nairobi, Kenya., Ng'ang'a W; Presidential Policy and Strategy Unit, The Presidency, Government of Kenya, Nairobi, Kenya., Adetifa IMO; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Wangeci Kagucia E; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Gallagher K; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Uyoga S; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Tsofa B; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Barasa E; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Bejon P; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom., Scott JAG; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Agweyu A; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Warimwe GM; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2022 Jan 29; Vol. 74 (2), pp. 288-293.
DOI:	10.1093/cid/ciab346
Abstrakt:	Background: Few studies have assessed the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers (HCWs) in Africa. We report findings from a survey among HCWs in 3 counties in Kenya. Methods: We recruited 684 HCWs from Kilifi (rural), Busia (rural), and Nairobi (urban) counties. The serosurvey was conducted between 30 July and 4 December 2020. We tested for immunoglobulin G antibodies to SARS-CoV-2 spike protein, using enzyme-linked immunosorbent assay. Assay sensitivity and specificity were 92.7 (95% CI, 87.9-96.1) and 99.0% (95% CI, 98.1-99.5), respectively. We adjusted prevalence estimates, using bayesian modeling to account for assay performance. Results: The crude overall seroprevalence was 19.7% (135 of 684). After adjustment for assay performance, seroprevalence was 20.8% (95% credible interval, 17.5%-24.4%). Seroprevalence varied significantly (P < .001) by site: 43.8% (95% credible interval, 35.8%-52.2%) in Nairobi, 12.6% (8.8%-17.1%) in Busia and 11.5% (7.2%-17.6%) in Kilifi. In a multivariable model controlling for age, sex, and site, professional cadre was not associated with differences in seroprevalence. Conclusion: These initial data demonstrate a high seroprevalence of antibodies to SARS-CoV-2 among HCWs in Kenya. There was significant variation in seroprevalence by region, but not by cadre. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu