Early introductions and transmission of SARS-CoV-2 variant B.1.1.7 in the United States.

Autor:	Alpert T; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA., Brito AF; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA., Lasek-Nesselquist E; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA., Rothman J; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA., Valesano AL; Department of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA., MacKay MJ; Tempus Labs, Chicago, IL 60654, USA., Petrone ME; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA., Breban MI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA., Watkins AE; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA., Vogels CBF; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA., Kalinich CC; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA., Dellicour S; Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Bruxelles, Belgium; Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium., Russell A; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA., Kelly JP; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA., Shudt M; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA., Plitnick J; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA., Schneider E; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA., Fitzsimmons WJ; Department of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA., Khullar G; Tempus Labs, Chicago, IL 60654, USA., Metti J; Tempus Labs, Chicago, IL 60654, USA., Dudley JT; Tempus Labs, Chicago, IL 60654, USA., Nash M; Tempus Labs, Chicago, IL 60654, USA., Beaubier N; Tempus Labs, Chicago, IL 60654, USA., Wang J; Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA., Liu C; Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA., Hui P; Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA., Muyombwe A; Connecticut State Department of Public Health, Rocky Hill, CT 06067, USA., Downing R; Connecticut State Department of Public Health, Rocky Hill, CT 06067, USA., Razeq J; Connecticut State Department of Public Health, Rocky Hill, CT 06067, USA., Bart SM; Connecticut State Department of Public Health, Rocky Hill, CT 06067, USA; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Grills A; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Morrison SM; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Murphy S; Murphy Medical Associates, Greenwich, CT 06830, USA., Neal C; Murphy Medical Associates, Greenwich, CT 06830, USA., Laszlo E; Murphy Medical Associates, Greenwich, CT 06830, USA., Rennert H; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA., Cushing M; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA., Westblade L; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA., Velu P; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA., Craney A; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA., Cong L; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA., Peaper DR; Departments of Laboratory Medicine and of Medicine, Yale School of Medicine, New Haven, CT 06510, USA., Landry ML; Departments of Laboratory Medicine and of Medicine, Yale School of Medicine, New Haven, CT 06510, USA., Cook PW; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA., Fauver JR; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA., Mason CE; Tempus Labs, Chicago, IL 60654, USA; Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA., Lauring AS; Department of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA., St George K; Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA; Department of Biomedical Sciences, University at Albany, SUNY, Albany, NY 12222, USA. Electronic address: kirsten.st.george@health.ny.gov., MacCannell DR; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA. Electronic address: fms2@cdc.gov., Grubaugh ND; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06510, USA. Electronic address: nathan.grubaugh@yale.edu.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2021 May 13; Vol. 184 (10), pp. 2595-2604.e13. Date of Electronic Publication: 2021 Apr 03.
DOI:	10.1016/j.cell.2021.03.061
Abstrakt:	The emergence and spread of SARS-CoV-2 lineage B.1.1.7, first detected in the United Kingdom, has become a global public health concern because of its increased transmissibility. Over 2,500 COVID-19 cases associated with this variant have been detected in the United States (US) since December 2020, but the extent of establishment is relatively unknown. Using travel, genomic, and diagnostic data, we highlight that the primary ports of entry for B.1.1.7 in the US were in New York, California, and Florida. Furthermore, we found evidence for many independent B.1.1.7 establishments starting in early December 2020, followed by interstate spread by the end of the month. Finally, we project that B.1.1.7 will be the dominant lineage in many states by mid- to late March. Thus, genomic surveillance for B.1.1.7 and other variants urgently needs to be enhanced to better inform the public health response. Competing Interests: Declarations of interests M.J.M., G.K., J.M., J.T.D., M.N., N.B., and C.E.M. work for Tempus Labs. K.S.G. receives research support from Thermo Fisher for the development of assays for the detection and characterization of viruses. The remaining authors declare no competing interests. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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