PREVALENCE OF TUBERCULOSIS, DRUG-RESISTANT TUBERCULOSIS AND HIV/TB CO-INFECTION IN ENUGU, NIGERIA.
| Autor: | Ugwu KO; Department of Microbiology, University of Nigeria, Nsukka, Nigeria., Agbo MC; Department of Pharmaceutical Microbiology and Biotechnology, University of Nigeria, Nsukka., Ezeonu IM; Department of Microbiology, University of Nigeria, Nsukka, Nigeria. |
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| Jazyk: | angličtina |
| Zdroj: | African journal of infectious diseases [Afr J Infect Dis] 2021 Mar 18; Vol. 15 (2), pp. 24-30. Date of Electronic Publication: 2021 Mar 18 (Print Publication: 2021). |
| DOI: | 10.21010/ajid.v15i2.5 |
| Abstrakt: | Background: Tuberculosis (TB) remains a global public health problem, with developing countries bearing the highest burden. Nigeria is first in Africa and sixth in the world among the countries with the highest TB burden, but is among the 10 countries accounting for over 70% of the global gap in TB case detection and notification. Enugu State, Nigeria reportedly has a notification gap of almost 14,000 TB cases; a situation which must be addressed. Materials and Methods: A total number of 868 individuals accessing DOTS services in designated centres within the six Local Government Areas (LGAs) of Enugu North geographical zone, was recruited into the study. The participants were screened for HIV seropositivity by standard protocols, while screening for TB and drug-resistant TB were conducted by a combination of Zhiel Neelsen staining and Nucleic Acid Amplification Test (Xpert ® MTB/Rif). Results: Of the 868 subjects that participated in the study, 176 (20.3%) were HIV seropositive. The highest prevalence (26.7%) of HIV was recorded in Udenu LGA, while the least (13.1%) was recorded in Nsukka LGA. Overall TB prevalence was found to be 22.1% and 21.3% by sputum-smear and NAAT, respectively. Uzo Uwani LGA recorded the highest prevalence of both TB (33.3%) and TB/HIV co-infection (16.7%), but the lowest prevalence of resistant TB. Nsukka LGA had the highest prevalence of resistant TB. Conclusion: Enugu North geographical zone, Nigeria, has a high prevalence of both HIV and TB, including resistant TB and there is need to increase monitoring of individuals resident in this region. Competing Interests: Conflict of Interest: Authors declare that there are no conflicts of interest. (Copyright: © 2021 Afr. J. Infect. Diseases.) |
| Databáze: | MEDLINE |
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