The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition.

Autor:	Li X; Department of Biology, Section of Microbiology, University of Copenhagen, 2100 Copenhagen, Denmark., Stokholm J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark., Brejnrod A; Skaggs School of Pharmacy, University of California, San Diego, La Jolla, CA 9500, USA., Vestergaard GA; Technical University of Denmark, Section of Bioinformatics, Department of Health Technology, 2800 Kongens Lyngby, Denmark., Russel J; Department of Biology, Section of Microbiology, University of Copenhagen, 2100 Copenhagen, Denmark., Trivedi U; Department of Biology, Section of Microbiology, University of Copenhagen, 2100 Copenhagen, Denmark., Thorsen J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark., Gupta S; Department of Biology, Section of Microbiology, University of Copenhagen, 2100 Copenhagen, Denmark., Hjelmsø MH; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark., Shah SA; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark., Rasmussen MA; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark., Sørensen SJ; Department of Biology, Section of Microbiology, University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address: sjs@bio.ku.dk.
Jazyk:	angličtina
Zdroj:	Cell host & microbe [Cell Host Microbe] 2021 Jun 09; Vol. 29 (6), pp. 975-987.e4. Date of Electronic Publication: 2021 Apr 21.
DOI:	10.1016/j.chom.2021.03.017
Abstrakt:	Antimicrobial resistance (AMR) is an accelerating global threat, yet the nature of AMR in the gut microbiome and how AMR is acquired during early life remain largely unknown. In a cohort of 662 Danish children, we characterized the antibiotic resistance genes (ARGs) acquired during the first year of life and assessed the impacts of diverse environmental exposures on ARG load. Our study reveals a clear bimodal distribution of ARG richness that is driven by the composition of the gut microbiome, especially E. coli. ARG profiles were significantly affected by various environmental factors. Among these factors, the importance of antibiotics diminished with time since treatment. Finally, ARG load and ARG clusters were also associated with the maturity of the gut microbiome and a bacterial composition associated with increased risk of asthma. These findings broaden our understanding of AMR in early life and have critical implications for efforts to mitigate its spread. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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