Coincident rapid expansion of two SARS-CoV-2 lineages with enhanced infectivity in Nigeria.

Autor:	Ozer EA; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Institute for Global Health, Chicago, IL, USA., Simons LM; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Institute for Global Health, Chicago, IL, USA., Adewumi OM; Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Infectious Disease Institute, College of Medicine, University of Ibadan, Ibadan, Nigeria., Fowotade AA; Infectious Disease Institute, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Biorepository and Clinical Virology Laboratory, College of Medicine, University College Hospital, University of Ibadan, Ibadan, Nigeria., Omoruyi EC; Biorepository and Clinical Virology Laboratory, College of Medicine, University College Hospital, University of Ibadan, Ibadan, Nigeria., Adeniji JA; Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.; Infectious Disease Institute, College of Medicine, University of Ibadan, Ibadan, Nigeria., Dean TJ; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Institute for Global Health, Chicago, IL, USA., Zayas J; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA., Bhimalli PP; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA., Ash MK; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA., Godzik A; University of California Riverside School of Medicine, Biosciences Division, Riverside, CA, USA., Schneider JR; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA., Mamede JI; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA., Taiwo BO; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Hultquist JF; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Institute for Global Health, Chicago, IL, USA., Lorenzo-Redondo R; Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Institute for Global Health, Chicago, IL, USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2021 Jul 02. Date of Electronic Publication: 2021 Jul 02.
DOI:	10.1101/2021.04.09.21255206
Abstrakt:	The emergence of new SARS-CoV-2 variants with enhanced transmissibility or decreased susceptibility to immune responses is a major threat to global efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Disparities in viral genomic surveillance capabilities and efforts have resulted in gaps in our understanding of the viral population dynamics across the globe. Nigeria, despite having the largest population of any nation in Africa, has had relatively little SARS-CoV-2 sequence data made publicly available. Here we report the whole-genome sequences of 74 SARS-CoV-2 isolates collected from individuals in Oyo State, Nigeria in January 2021. Most isolates belonged to either the B.1.1.7 Alpha "variant of concern" or the B.1.525 Eta lineage, which is currently considered a "variant of interest" containing multiple spike protein mutations previously associated with enhanced transmissibility and possible immune escape. Nigeria has the highest reported frequency of the B.1.525 lineage globally with phylogenetic characteristics consistent with a recent monophyletic origin and rapid expansion. Spike protein from the B.1.525 lineage displayed both increased infectivity and decreased neutralization by convalescent sera compared to Spike proteins from other clades. These results, along with indications that the virus is outpacing the B.1.1.7 lineage in Nigeria, suggest that the B.1.525 lineage represents another "variant of concern" and further underline the importance of genomic surveillance in undersampled regions across the globe. Competing Interests: CONFLICTS OF INTEREST None.
Databáze:	MEDLINE
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