Insecticide Resistance Patterns and Mechanisms in Aedes aegypti (Diptera: Culicidae) Populations Across Abidjan, Côte d'Ivoire Reveal Emergent Pyrethroid Resistance.

Autor:	Konan LY; National Institute of Public Hygiene, Abidjan, Côte d'Ivoire., Oumbouke WA; Department of Disease Control, London School of Hygiene and Tropical Medicine, LondonUK., Silué UG; National Institute of Public Hygiene, Abidjan, Côte d'Ivoire.; Laboratory of Zoology and Animal Biology, UFR Biosciences, Felix Houphouet-Boigny University, Abidjan, Côte d'Ivoire., Coulibaly IZ; Unit of Entomology and Herpetology, Pasteur Institute of Côte d'Ivoire, Abidjan, Côte d'Ivoire., Ziogba JT; National Institute of Public Hygiene, Abidjan, Côte d'Ivoire., N'Guessan RK; Department of Disease Control, London School of Hygiene and Tropical Medicine, LondonUK., Coulibaly D; National Institute of Public Hygiene, Abidjan, Côte d'Ivoire., Bénié JBV; National Institute of Public Hygiene, Abidjan, Côte d'Ivoire., Lenhart A; Entomology Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jazyk:	angličtina
Zdroj:	Journal of medical entomology [J Med Entomol] 2021 Jul 16; Vol. 58 (4), pp. 1808-1816.
DOI:	10.1093/jme/tjab045
Abstrakt:	From 2008 to 2017, the city of Abidjan, Côte d'Ivoire experienced several Aedes-borne disease epidemics which required control of the vector mosquito population based on the reduction of larval habitats and insecticidal sprays for adult mosquitoes. This study was undertaken to assess the insecticide susceptibility status of Aedes aegypti (Linnaeus) in the city of Abidjan. Immature Ae. aegypti were sampled from several larval habitats within seven communes of Abidjan and reared to adults. Three to five days old F1 emerged adults were tested for susceptibility using insecticide-impregnated papers and the synergist piperonyl butoxide (PBO) following WHO bioassay guidelines. The results showed that Ae. aegypti populations from Abidjan were resistant to 0.1% propoxur, and 1% fenitrothion, with mortality rates ranging from 0% to 54.2%. Reduced susceptibility (93.4-97.5% mortality) was observed to 0.05% deltamethrin, 0.75% permethrin, 0.05% lambda-cyhalothrin, 5% malathion, and 0.8% chlorpyrifos-methyl. This reduced susceptibility varied depending on the insecticide and the collection site. The restoration of mortality when the mosquitoes were pre-exposed to the synergist PBO suggests that increased activity of oxidases could be contributing to resistance. Three kdr mutations (V410L, V1016I, and F1534C) were present in populations tested, with low frequencies for the Leu410 (0.28) and Ile1016 (0.32) alleles and high frequencies for the Cys1534 allele (0.96). These findings will be used to inform future arbovirus vector control activities in Abidjan. (© The Author(s) 2021. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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