Tertiary lymphoid structures in epithelioid malignant peritoneal mesothelioma are associated with neoadjuvant chemotherapy, but not with prognosis.

Autor: Benzerdjeb N; Department of Pathology, Institut de Pathologie Multisite, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France. nazim.benzerdjeb@chu-lyon.fr., Dartigues P; Department of Pathology, Gustave Roussy Institute, Villejuif, France., Kepenekian V; Department of Digestive Surgery, Lyon University Hospital, F-69000, Lyon, France., Valmary-Degano S; Department of Pathology, Grenoble University Hospital, Grenoble, France., Mery E; Department of Pathology, Claudius Regaud Institute, IUTC Oncopôle, Toulouse, France., Avérous G; Department of Pathology, CHU Strasbourg, Strasbourg, France., Chevallier A; Department of Pathology, CHU l'Archet II, Nice, France., Laverriere MH; Department of Pathology, Grenoble University Hospital, Grenoble, France., Villa I; Department of Pathology, Gustave Roussy Institute, Villejuif, France., Harou O; Department of Pathology, Institut de Pathologie Multisite, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France., Sallé FG; MESOPATH, Department of Biopathology, Centre Léon Bérard, Lyon, France., Villeneuve L; Service d'Epidémiologie et de Recherche Cliniques, Pôle de Santé Publique, Hospices Civils de Lyon, Lyon, France., Glehen O; Department of Digestive Surgery, Lyon University Hospital, F-69000, Lyon, France., Isaac S; Department of Pathology, Institut de Pathologie Multisite, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France., Hommell-Fontaine J; Department of Pathology, Institut de Pathologie Multisite, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre-Bénite, France., Bibeau F; Department of Pathology, Caen University Hospital, University of Caen Normandie, Caen, France.
Jazyk: angličtina
Zdroj: Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Oct; Vol. 479 (4), pp. 765-772. Date of Electronic Publication: 2021 Apr 14.
DOI: 10.1007/s00428-021-03099-1
Abstrakt: Epithelioid mesothelioma is the most prevalent subtype of diffuse malignant peritoneal mesothelioma. The relationship between a strong adaptive immune response and a better prognosis in malignant solid tumors is widely known. Due to the low incidence of epithelioid malignant peritoneal mesothelioma (EMPM), very little is known about their immune micro-environment. We encountered several cases of tertiary lymphoid structures in EMPM in a previous study and aimed to investigate in the same series the prevalence, clinicopathological features, and the prognostic impact associated with tertiary lymphoid structures in EMPM (TLS-EMPM). Cases of EMPM, from 1995 to 2018, were retrieved from 7 French institutions from the RENAPE Network. The predictions in terms of overall survival (OS) and progression-free survival (PFS) of TLS-EMPM were analyzed. We report 52 cases of TLS-EMPM among a series of 138 cases of EMPM. TLS-EMPM was significantly associated with neoadjuvant chemotherapy, and was not a prognostic indicator for OS (p = 0.652) and PFS (p = 0.804) in our series. TLS is a component of the host immune response to EMPM significantly associated with neoadjuvant chemotherapy, but was not a predictor of prognosis for overall and progression-free survivals in this series. These findings provide another possible etiology for tertiary lymphoid structures.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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