A Time Duration Discrimination Task for the Study of Elapsed Time Processing in Rats.

Autor:	Tenney S; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA, USA., Vogiatzoglou E; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA, USA., Chohan D; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA, USA., Vo A; Department of Psychological Sciences, University of San Diego, San Diego, CA, USA., Hunt T; Department of Psychological Sciences, University of San Diego, San Diego, CA, USA., Cayanan K; Department of Psychological Sciences, University of San Diego, San Diego, CA, USA., Hales JB; Department of Psychological Sciences, University of San Diego, San Diego, CA, USA., Sabariego M; Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA, USA.
Jazyk:	angličtina
Zdroj:	Bio-protocol [Bio Protoc] 2021 Mar 20; Vol. 11 (6), pp. e3965. Date of Electronic Publication: 2021 Mar 20 (Print Publication: 2021).
DOI:	10.21769/BioProtoc.3965
Abstrakt:	Space and time are both essential features of episodic memory. However, while spatial tasks have been used effectively to study the behavioral relevance of place cells, the behavioral paradigms utilized for the study of time cells have not used time duration as a variable that animals need to be aware of to solve the task. In order to evaluate how time flow is coded into memory, time duration needs to be a variable that animals use to solve the behavioral task. This protocol describes a novel behavioral paradigm, the time duration discrimination (TDD) task, which is designed to directly investigate the neurological mechanisms that underlie temporal processing. During the TDD task, rats navigate around a Figure-8 Maze, which contains a rectangular track with a central arm and a delay box at the end of the central arm. While confined to the delay box, rats experience a 10- or 20-second time delay, during which a tone will play for the duration of the 10- or 20-second delay. When the delay box opens, the rat will choose whether to turn left or right out of the delay box and receive a reward for the correct choice ( e.g. , 10 seconds = left turn; 20 seconds = right turn). By directly manipulating elapsed time, we can better explore the behavioral relevance of hippocampal time cells and whether the time-dependent activity seen in physiological recordings of hippocampal neurons reflects a neuronal representation of time flow that can be used by the animal for learning and storing memories. Graphic abstract: Elapsed time duration discrimination in rats . Competing Interests: Competing interestsThe authors have no conflicts of interest. (Copyright © 2021 The Authors; exclusive licensee Bio-protocol LLC.)
Databáze:	MEDLINE
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