Endogenous Progestogens and Colorectal Cancer Risk among Postmenopausal Women.
| Autor: | Michels KA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland. kara.michels@nih.gov., Geczik AM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Bauer DC; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.; Department of Medicine, University of California San Francisco, San Francisco, California., Brinton LA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Buist DSM; Kaiser Permanente Washington Health Research Institute, Seattle, Washington., Cauley JA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Dallal CM; School of Public Health, University of Maryland, College Park, Maryland., Falk RT; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Hue TF; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California., Lacey JV Jr; Department of Computational and Quantitative Medicine, Division of Health Analytics, City of Hope, Duarte, California., LaCroix AZ; Department of Family and Preventive Medicine, Division of Epidemiology, University of California San Diego, San Diego, California., Tice JA; Department of Medicine, University of California San Francisco, San Francisco, California., Xu X; Leidos Biomedical Research, Inc., Frederick, Maryland., Trabert B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland. |
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| Jazyk: | angličtina |
| Zdroj: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2021 Jun; Vol. 30 (6), pp. 1100-1105. Date of Electronic Publication: 2021 Apr 07. |
| DOI: | 10.1158/1055-9965.EPI-20-1568 |
| Abstrakt: | Background: The role of progestogens in colorectal cancer development is poorly characterized. To address this, our group developed a highly sensitive assay to measure concentrations of seven markers of endogenous progestogen metabolism among postmenopausal women. Methods: The markers were measured in baseline serum collected from postmenopausal women in a case-cohort study within the breast and bone follow-up to the fracture intervention trial (B∼FIT). We followed women not using exogenous hormones at baseline (1992-1993) for up to 12 years: 187 women with incident colorectal cancer diagnosed during follow-up and a subcohort of 495 women selected on strata of age and clinical center. We used adjusted Cox regression models with robust variance to estimate risk for colorectal cancer [hazard ratios (HR), 95% confidence intervals (CI)]. Results: High concentrations of pregnenolone and progesterone were not associated with colorectal cancer [quintile(Q)5 versus Q1: pregnenolone HR, 0.71, 95% CI, 0.40-1.25; progesterone HR, 1.25; 95% CI, 0.71-2.22]. A trend of increasing risk was suggested, but statistically imprecise across quintiles of 17-hydroxypregnenolone (Q2 to Q5 HRs, 0.75-1.44; P Conclusions: We used sensitive and reliable assays to measure multiple circulating markers of progestogen metabolism. Progestogens were generally unassociated with colorectal cancer risk in postmenopausal women. Impact: Our findings are consistent with most prior research on circulating endogenous sex hormones, which taken together suggest that sex hormones may not be major drivers of colorectal carcinogenesis in postmenopausal women. (©2021 American Association for Cancer Research.) |
| Databáze: | MEDLINE |
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