Enzymes of Polyphosphate Metabolism in Yeast: Properties, Functions, Practical Significance.

Autor: Kulakovskaya TV; Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Research Center for Biology, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. alla@ibpm.pushchino.ru., Andreeva NA; Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Research Center for Biology, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia., Ledova LA; Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Research Center for Biology, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia., Ryazanova LP; Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Research Center for Biology, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia., Trilisenko LV; Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Research Center for Biology, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia., Eldarov MA; Institute of Bioengineering, Federal Scientific Center for Biotechnology, Russian Academy of Sciences, Moscow, 117312, Russia.
Jazyk: angličtina
Zdroj: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2021 Jan; Vol. 86 (Suppl 1), pp. S96-S108.
DOI: 10.1134/S0006297921140078
Abstrakt: Inorganic polyphosphates (polyP) are the linear polymers of orthophosphoric acid varying in the number of phosphate residues linked by the energy-rich phosphoanhydride bonds. PolyP is an essential component in living cells. Knowledge of polyP metabolizing enzymes in eukaryotes is necessary for understanding molecular mechanisms of polyP metabolism in humans and development of new approaches for treating bone and cardiovascular diseases associated with impaired mineral phosphorus metabolism. Yeast cells represent a rational experimental model for this research due to availability of the methods for studying phosphorus metabolism and construction of knockout mutants and strains overexpressing target proteins. Multicomponent system of polyP metabolism in Saccharomyces cerevisiae cells is presented in this review discussing properties, functioning, and practical significance of the enzymes involved in the synthesis and degradation of this important metabolite.
Databáze: MEDLINE
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