Central macular thickness in patients with sickle cell disease and no signs of retinopathy: a cross-sectional study of Jordanian patients.

Autor:	Abu-Yaghi NE; Special Surgery Department/Ophthalmology Division, School of Medicine, University of Jordan, Amman, Jordan., AlNawaiseh AM; School of Medicine, University of Jordan, Amman, Jordan., Khourshid IM; School of Medicine, University of Jordan, Amman, Jordan., AlRawashdeh TJ; School of Medicine, University of Jordan, Amman, Jordan., Rawashdeh MMA; School of Medicine, University of Jordan, Amman, Jordan., Zghoul AM; School of Medicine, University of Jordan, Amman, Jordan., Shafagoj AN; School of Medicine, University of Jordan, Amman, Jordan., Alomairi YA; School of Medicine, University of Jordan, Amman, Jordan., Muhsen SM; Special Surgery Department/Ophthalmology Division, School of Medicine, University of Jordan, Amman, Jordan., AlRyalat SS; Special Surgery Department/Ophthalmology Division, School of Medicine, University of Jordan, Amman, Jordan.
Jazyk:	angličtina
Zdroj:	The Journal of international medical research [J Int Med Res] 2021 Apr; Vol. 49 (4), pp. 300060520977387.
DOI:	10.1177/0300060520977387
Abstrakt:	Objectives: To measure central macular thickness in Jordanian patients with sickle cell disease who did not have retinopathy and compare the findings with age- and sex-matched controls using spectral domain optical coherence tomography (SDOCT). Methods: In this cross-sectional study, participants underwent visual acuity testing, slit-lamp bio-microscopy, dilated ophthalmoscopy, and SDOCT imaging to measure central macular thickness. Macular quadrant measurements and thickness difference indexes (TDIs) were compared between groups. Results: Twenty eyes with sickle cell disease and 20 control eyes were enrolled. The median visual acuity in both groups was 20/20. The mean macular thickness was significantly lower in eyes with sickle cell disease than in matched controls (mean difference, 22.15 ± 6.44 µm). Peripheral quadrants were all significantly thinner in eyes with sickle cell disease, especially in superior and temporal quadrants. TDIs were lower in eyes with sickle cell disease than in control eyes. Conclusions: Eyes with sickle cell disease that had no clinical evidence of retinopathy exhibited significantly lower central macular thickness in all quadrants, compared with eyes in age- and sex-matched controls. SDOCT is a non-invasive imaging modality that can detect preclinical changes in eyes with sickle cell disease and can be used to screen and monitor the disease process.
Databáze:	MEDLINE
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