Glycogen-rich clear cell carcinoma of the breast with solid papillary pattern: Two cases with heterogeneous clinicopathological features.

Autor:	Georgescu TA; Department of Pathology, 'Alessandrescu-Rusescu' National Institute for Mother and Child Health, 020395 Bucharest, Romania.; Discipline of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Munteanu O; Department of Obstetrics and Gynecology, Emergency University Hospital of Bucharest, 050098 Bucharest, Romania.; Discipline of Anatomy, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Lisievici AC; Discipline of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Tebeică T; Department of Pathology, Dr Leventer Centre, 011216 Bucharest, Romania., Crețoiu D; Department of Genetics, 'Alessandrescu-Rusescu' National Institute for Mother and Child Health, 020395 Bucharest, Romania.; Discipline of Histology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Toader O; Department of Obstetrics and Gynecology, 'Alessandrescu-Rusescu' National Institute for Mother and Child Health, 020395 Bucharest, Romania.; Discipline of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Suciu N; Department of Obstetrics and Gynecology, 'Alessandrescu-Rusescu' National Institute for Mother and Child Health, 020395 Bucharest, Romania.; Discipline of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Bohîlțea RE; Department of Obstetrics and Gynecology, Emergency University Hospital of Bucharest, 050098 Bucharest, Romania.; Discipline of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Jazyk:	angličtina
Zdroj:	Experimental and therapeutic medicine [Exp Ther Med] 2021 May; Vol. 21 (5), pp. 524. Date of Electronic Publication: 2021 Mar 22.
DOI:	10.3892/etm.2021.9956
Abstrakt:	Invasive breast cancer is a heterogeneous disease, both in its histopathological classification and clinical course. Glycogen-rich clear cell carcinoma of the breast is an extremely rare subtype of invasive breast carcinoma, accounting for up to 3% of all breast carcinomas. The tumor is composed of polygonal cells with abundant clear cytoplasm containing glycogen and has a very controversial prognosis. Solid papillary pattern is an uncommon morphological variant of breast carcinoma which is associated with indolent behavior in the absence of an invasive component. To date, there are only three cases of glycogen-rich clear cell carcinoma with solid papillary pattern reported in the English literature. In this article, we present two cases of glycogen-rich clear cell carcinoma of the breast, encountered in our daily clinical practice over a period of 5 years (2015-2020) and perform a brief review of currently published literature. Unlike most cases of glycogen-rich clear cell carcinoma documented to date, follow-up of our case featuring solid papillary pattern revealed extremely favorable clinical outcome, suggesting a better prognosis for tumors with this morphology. Competing Interests: The authors declare that they have no competing interests. (Copyright: © Georgescu et al.)
Databáze:	MEDLINE
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