Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space.

Autor:	Ko DJ; Department of Anatomy, Physiology & Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Kelly T; Department of Anatomy, Physiology & Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Thompson L; Department of Anatomy, Physiology & Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Uppal JK; Department of Anatomy, Physiology & Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Rostampour N; Department of Anatomy, Physiology & Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Webb MA; Canadian Light Source, University of Saskatchewan, 44 Innovation Boulevard, Saskatoon, SK S7N 2V3, Canada., Zhu N; Canadian Light Source, University of Saskatchewan, 44 Innovation Boulevard, Saskatoon, SK S7N 2V3, Canada., Belev G; Canadian Light Source, University of Saskatchewan, 44 Innovation Boulevard, Saskatoon, SK S7N 2V3, Canada., Mondal P; Clinical Research Support Unit, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Cooper DML; Department of Anatomy, Physiology & Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada., Boughner JC; Department of Anatomy, Physiology & Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada.
Jazyk:	angličtina
Zdroj:	Journal of developmental biology [J Dev Biol] 2021 Mar 12; Vol. 9 (1). Date of Electronic Publication: 2021 Mar 12.
DOI:	10.3390/jdb9010008
Abstrakt:	For humans and other mammals to eat effectively, teeth must develop properly inside the jaw. Deciphering craniodental integration is central to explaining the timely formation of permanent molars, including third molars which are often impacted in humans, and to clarifying how teeth and jaws fit, function and evolve together. A factor long-posited to influence molar onset time is the jaw space available for each molar organ to form within. Here, we tested whether each successive molar initiates only after a minimum threshold of space is created via jaw growth. We used synchrotron-based micro-CT scanning to assess developing molars in situ within jaws of C57BL/6J mice aged E10 to P32, encompassing molar onset to emergence. We compared total jaw, retromolar and molar lengths, and molar onset times, between upper and lower jaws. Initiation time and developmental duration were comparable between molar upper and lower counterparts despite shorter, slower-growing retromolar space in the upper jaw, and despite size differences between upper and lower molars. Timing of molar formation appears unmoved by jaw length including space. Conditions within the dental lamina likely influence molar onset much more than surrounding jaw tissues. We theorize that molar initiation is contingent on sufficient surface area for the physical reorganization of dental epithelium and its invagination of underlying mesenchyme.
Databáze:	MEDLINE
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