SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients.

Autor: Hussein UK; Department of Pathology, Jeonbuk National University Medical School, Jeonju 54896, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea.; Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt., Ahmed AG; Department of Pathology, Jeonbuk National University Medical School, Jeonju 54896, Korea.; Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62511, Egypt., Choi WK; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea.; Department of Obstetrics and Gynecology, Jeonbuk National University Medical School, Jeonju 54896, Korea., Kim KM; Department of Pathology, Jeonbuk National University Medical School, Jeonju 54896, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea., Park SH; Department of Bio and Chemical Engineering, Hongik University, Sejong 30016, Korea., Park HS; Department of Pathology, Jeonbuk National University Medical School, Jeonju 54896, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea., Noh SJ; Department of Forensic Medicine, Jeonbuk National University Medical School, Jeonju 54896, Korea., Lee H; Department of Forensic Medicine, Jeonbuk National University Medical School, Jeonju 54896, Korea., Chung MJ; Department of Pathology, Jeonbuk National University Medical School, Jeonju 54896, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea., Moon WS; Department of Pathology, Jeonbuk National University Medical School, Jeonju 54896, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea., Kang MJ; Department of Pathology, Jeonbuk National University Medical School, Jeonju 54896, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea., Cho DH; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea.; Department of Obstetrics and Gynecology, Jeonbuk National University Medical School, Jeonju 54896, Korea., Jang KY; Department of Pathology, Jeonbuk National University Medical School, Jeonju 54896, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea.
Jazyk: angličtina
Zdroj: Biomolecules [Biomolecules] 2021 Mar 09; Vol. 11 (3). Date of Electronic Publication: 2021 Mar 09.
DOI: 10.3390/biom11030405
Abstrakt: SCRIB is a polarity protein important in maintaining cell junctions. However, recent reports have raised the possibility that SCRIB might have a role in human cancers. Thus, this study evaluated the roles of SCRIB in ovarian cancers. In 102 human ovarian carcinomas, nuclear expression of SCRIB predicted shorter survival of ovarian carcinoma patients, especially in the patients who received post-operative chemotherapy. In SKOV3 and SNU119 ovarian cancer cells, overexpression of SCRIB stimulated the proliferation and invasion of cells. Knockout of SCRIB inhibited in vivo tumor growth of SKOV3 cells and overexpression of SCRIB promoted tumor growth. Overexpression of SCRIB stimulated epithelial-to-mesenchymal transition by increasing the expression of N-cadherin, snail, TGF-β1, and smad2/3, and decreasing the expression of E-cadherin; the converse was observed with inhibition of SCRIB. In conclusion, this study presents the nuclear expression of SCRIB as a prognostic marker of ovarian carcinomas and suggests that SCRIB is involved in the progression of ovarian carcinomas by stimulating proliferation and epithelial-to-mesenchymal transition-related invasiveness.
Databáze: MEDLINE
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