Molecular Mechanisms for Bacterial Potassium Homeostasis.

Autor: Stautz J; Institute of Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany., Hellmich Y; Institute of Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany., Fuss MF; Institute of Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany., Silberberg JM; Institute of Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany., Devlin JR; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States., Stockbridge RB; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States. Electronic address: stockbr@umich.edu., Hänelt I; Institute of Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany. Electronic address: haenelt@biochem.uni-frankfurt.de.
Jazyk: angličtina
Zdroj: Journal of molecular biology [J Mol Biol] 2021 Aug 06; Vol. 433 (16), pp. 166968. Date of Electronic Publication: 2021 Mar 30.
DOI: 10.1016/j.jmb.2021.166968
Abstrakt: Potassium ion homeostasis is essential for bacterial survival, playing roles in osmoregulation, pH homeostasis, regulation of protein synthesis, enzyme activation, membrane potential adjustment and electrical signaling. To accomplish such diverse physiological tasks, it is not surprising that a single bacterium typically encodes several potassium uptake and release systems. To understand the role each individual protein fulfills and how these proteins work in concert, it is important to identify the molecular details of their function. One needs to understand whether the systems transport ions actively or passively, and what mechanisms or ligands lead to the activation or inactivation of individual systems. Combining mechanistic information with knowledge about the physiology under different stress situations, such as osmostress, pH stress or nutrient limitation, one can identify the task of each system and deduce how they are coordinated with each other. By reviewing the general principles of bacterial membrane physiology and describing the molecular architecture and function of several bacterial K + -transporting systems, we aim to provide a framework for microbiologists studying bacterial potassium homeostasis and the many K + -translocating systems that are still poorly understood.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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