Prevented Sudden Cardiac Death and Neurologic Recovery in Inherited Heart Diseases.

Autor:	Hernández Del Rincón JP; Instituto de Medicina Legal y Ciencias Forenses, Murcia, Spain.; Departamento de Medicina Legal, Universidad de Murcia, Murcia, Spain.; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain., Olmo Conesa MC; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain.; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain., Rodríguez Serrano A; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain., García Pulgar H; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain., López Cuenca D; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain.; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain., Muñoz Esparza C; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain.; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain., Navarro Peñalver M; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain.; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain., Santos Mateo JJ; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain.; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain., Nicolás Rocamora E; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain.; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.; Departamento de Medicina Interna, Universidad de Murcia, Murcia, Spain., Gil Ortuño C; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain.; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain., Sabater-Molina M; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain.; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.; Departamento de Medicina Interna, Universidad de Murcia, Murcia, Spain.; European Reference Networks (Guard-Heart), Amsterdam, Netherlands.; Red de investigación Cardiovascular (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain., Gimeno Blanes JR; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain.; Unidad de Cardiopatías Hereditarias, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.; Departamento de Medicina Interna, Universidad de Murcia, Murcia, Spain.; European Reference Networks (Guard-Heart), Amsterdam, Netherlands.; Red de investigación Cardiovascular (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain., Pastor Quirante F; Instituto Murciano, de Investigación Biosanitaria (IMIB), Murcia, Spain.; Servicio de Anatomía Patológica, Hospital General Universitario Reina Sofía, Murcia, Spain.; Departamento de Anatomia Patologica, Universidad de Murcia, Murcia, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2021 Mar 15; Vol. 8, pp. 634300. Date of Electronic Publication: 2021 Mar 15 (Print Publication: 2021).
DOI:	10.3389/fcvm.2021.634300
Abstrakt:	Introduction: Inherited cardiovascular diseases are an important cause of sudden cardiac death (SD). The use of risk scores identify high risk patients who would benefit from an implantable cardioverter-defibrillators (ICDs). The development of automated devices for out-of-hospital cardiac arrest improves early resuscitation. The objective of the study is to quantify prevented SD and the neurological recovery of patients with inherited cardiovascular diseases. Methods: Two hundred fifty-seven cases of SD (age 42 ± 18 years, 79.4% men) of non-ischemic cardiac cause were prospectively collected during the study period (2009-17). Fifty three (20.6%) had a resuscitated cardiac arrest (RCA) (age 40 ± 18 years, 64.2% male). Epidemiological, clinical and autopsy aspects were analyzed. Prevented SD was defined as a combination of RCA and appropriate ICD therapy cases. Results: An autopsy was performed in 157/204 (77.0%) cases who died. There were 19 (12.1%) cases with a negative autopsy. The diagnosis of cardiomyopathy and channelopathy was 58.0 and 18.7%, respectively. Female sex and confirmed or suspected channelopathy were associated with successful resuscitation. The percentage of prevented SD remained low during the study period (mean 35.6%). 60.4% of RCA cases presented good neurological outcome. There was no association between neurological recovery and therapeutic hypothermia, but there was association with time of resuscitation (min). Conclusion: A fifth part of non-ischemic cardiac arrests were resuscitated. Female sex and channelopathies were more prevalent among RCA. Two thirds of RCA had a good neurological recovery. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Hernández del Rincón, Olmo Conesa, Rodríguez Serrano, García Pulgar, López Cuenca, Muñoz Esparza, Navarro Peñalver, Santos Mateo, Nicolás Rocamora, Gil Ortuño, Sabater-Molina, Gimeno Blanes and Pastor Quirante.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu