Esophageal Pemphigus Vulgaris: A Rare Etiology of Upper Gastrointestinal Hemorrhage.

Autor: Del Castillo JRF; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD 21218, USA.; MedStar Good Samaritan Hospital, Baltimore, MD 21239, USA.; MedStar Franklin Square Medical Center, Baltimore, MD 21237, USA.; MedStar Harbor Hospital, Baltimore, MD 21225, USA., Yousaf MN; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD 21218, USA.; MedStar Good Samaritan Hospital, Baltimore, MD 21239, USA.; MedStar Franklin Square Medical Center, Baltimore, MD 21237, USA.; MedStar Harbor Hospital, Baltimore, MD 21225, USA., Chaudhary FS; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD 21218, USA.; MedStar Good Samaritan Hospital, Baltimore, MD 21239, USA.; MedStar Franklin Square Medical Center, Baltimore, MD 21237, USA.; MedStar Harbor Hospital, Baltimore, MD 21225, USA., Saleh N; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD 21218, USA.; MedStar Good Samaritan Hospital, Baltimore, MD 21239, USA.; MedStar Franklin Square Medical Center, Baltimore, MD 21237, USA.; MedStar Harbor Hospital, Baltimore, MD 21225, USA., Mills L; Department of Gastroenterology, MedStar Good Samaritan Hospital, Baltimore, MD 21239, USA.
Jazyk: angličtina
Zdroj: Case reports in gastrointestinal medicine [Case Rep Gastrointest Med] 2021 Mar 18; Vol. 2021, pp. 5555961. Date of Electronic Publication: 2021 Mar 18 (Print Publication: 2021).
DOI: 10.1155/2021/5555961
Abstrakt: Pemphigus vulgaris (PV) is an autoimmune blistering disorder of the skin and mucosal surfaces characterized by acantholysis (loss of adhesion between epidermal cells). Esophageal involvement of PV is an underdiagnosed entity as routine diagnostic endoscopy is not recommended in asymptomatic patients. Dysphagia and odynophagia are common presenting symptoms; however, upper gastrointestinal bleeding (UGIB) associated with esophageal involvement of PV without a history of mucosal blistering is extremely uncommon. We present a case of esophageal involvement of PV associated with active UGIB that was diagnosed on endoscopic evaluation. This case illustrated the importance of early endoscopy to identify the esophageal involvement of PV especially in patients with preexisting disease who present with gastrointestinal symptoms such as dysphagia, odynophagia, and hematemesis. Early recognition of esophageal involvement of PV and initiation of corticosteroid and/or immunosuppressant therapy may improve the outcome of the disease.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2021 Jennifer Rose F. Del Castillo et al.)
Databáze: MEDLINE
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