The Role of Ribosomal Protein S6 Kinases in Plant Homeostasis.

Autor:	Obomighie I; School of Life Sciences, University of Essex, Colchester, United Kingdom., Lapenas K; School of Life Sciences, University of Essex, Colchester, United Kingdom., Murphy BE; School of Life Sciences, University of Essex, Colchester, United Kingdom., Bowles AMC; School of Life Sciences, University of Essex, Colchester, United Kingdom., Bechtold U; School of Life Sciences, University of Essex, Colchester, United Kingdom., Prischi F; School of Life Sciences, University of Essex, Colchester, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in molecular biosciences [Front Mol Biosci] 2021 Mar 10; Vol. 8, pp. 636560. Date of Electronic Publication: 2021 Mar 10 (Print Publication: 2021).
DOI:	10.3389/fmolb.2021.636560
Abstrakt:	The p70 ribosomal S6 kinase (S6K) family is a group of highly conserved kinases in eukaryotes that regulates cell growth, cell proliferation, and stress response via modulating protein synthesis and ribosomal biogenesis. S6Ks are downstream effectors of the Target of Rapamycin (TOR) pathway, which connects nutrient and energy signaling to growth and homeostasis, under normal and stress conditions. The plant S6K family includes two isoforms, S6K1 and S6K2, which, despite their high level of sequence similarity, have distinct functions and regulation mechanisms. Significant advances on the characterization of human S6Ks have occurred in the past few years, while studies on plant S6Ks are scarce. In this article, we review expression and activation of the two S6K isoforms in plants and we discuss their roles in mediating responses to stresses and developmental cues. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Obomighie, Lapenas, Murphy, Bowles, Bechtold and Prischi.)
Databáze:	MEDLINE
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