| Autor: |
Zhang WY; Department of Chemistry, University of Warwick, CV4 7AL, Coventry, UK., Bridgewater HE; Department of Chemistry, University of Warwick, CV4 7AL, Coventry, UK., Banerjee S; Department of Chemistry, University of Warwick, CV4 7AL, Coventry, UK., Soldevila-Barreda JJ; Department of Chemistry, University of Warwick, CV4 7AL, Coventry, UK., Clarkson GJ; Department of Chemistry, University of Warwick, CV4 7AL, Coventry, UK., Shi H; Department of Chemistry, University of Warwick, CV4 7AL, Coventry, UK., Imberti C; Department of Chemistry, University of Warwick, CV4 7AL, Coventry, UK., Sadler PJ; Department of Chemistry, University of Warwick, CV4 7AL, Coventry, UK. |
| Abstrakt: |
We report the synthesis, characterisation and cytotoxicity of six cyclometalated rhodium(III) complexes [Cp X Rh(C^N)Z] 0/+ , in which Cp X = Cp*, Cp ph , or Cp biph , C^N = benzo[h]quinoline, and Z = chloride or pyridine. Three x-ray crystal structures showing the expected "piano-stool" configurations have been determined. The chlorido complexes hydrolysed faster in aqueous solution, also reacted preferentially with 9-ethyl guanine or glutathione compared to their pyridine analogues. The 1-biphenyl-2,3,4,5,-tetramethylcyclopentadienyl complex [Cp biph Rh(benzo[h]quinoline)Cl] ( 3a ) was the most efficient catalyst in coenzyme reduced nicotinamide adenine dinucleotide (NADH) oxidation to NAD + and induced an elevated level of reactive oxygen species (ROS) in A549 human lung cancer cells. The pyridine complex [Cp biph Rh(benzo[h]quinoline)py] + ( 3b ) was the most potent against A549 lung and A2780 ovarian cancer cell lines, being 5-fold more active than cisplatin towards A549 cells, and acted as a ROS scavenger. This work highlights a ligand-controlled strategy to modulate the reactivity and cytotoxicity of cyclometalated rhodium anticancer complexes. |
