Risk factors associated with the development of oral mucositis in pediatric oncology patients: Systematic review and meta-analysis.

Autor: de Farias Gabriel A; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Silveira FM; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Curra M; Department of Oral Pathology, University of Caxias do Sul (UCS), Caxias do Sul, Porto Alegre, Brazil., Schuch LF; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Wagner VP; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Martins MAT; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.; Department of Oral Medicine, Hospital de Clínicas de Porto Alegre (HCPA/UFRGS), Porto Alegre, Brazil., da Silveira Matte U; Molecular and Protein Analysis Unit (UAMP), Hospital de Clínicas de Porto Alegre (HCPA/UFRGS), Porto Alegre, Brazil., Siebert M; Molecular and Protein Analysis Unit (UAMP), Hospital de Clínicas de Porto Alegre (HCPA/UFRGS), Porto Alegre, Brazil., Botton MR; Molecular and Protein Analysis Unit (UAMP), Hospital de Clínicas de Porto Alegre (HCPA/UFRGS), Porto Alegre, Brazil., Brunetto AT; Childhood Cancer Institute, Porto Alegre, Brazil., Gregianin LJ; Department of Pediatric Oncology, Porto Alegre Clínicas Hospital (HCPA/UFRGS), Porto Alegre, Brazil., Martins MD; Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.; Department of Oral Medicine, Hospital de Clínicas de Porto Alegre (HCPA/UFRGS), Porto Alegre, Brazil.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2022 May; Vol. 28 (4), pp. 1068-1084. Date of Electronic Publication: 2021 Apr 09.
DOI: 10.1111/odi.13863
Abstrakt: Objectives: Oral mucositis (OM) is an acute toxicity related to cancer treatment. This systematic review aimed to identify potential risk factors associated with the development of OM in pediatric cancer patients.
Methods: A search was performed in four electronic databases to identify studies that analyzed risk factors for OM in pediatric cancer patients.
Results: Nineteen articles were included. The incidence of OM ranged from 20% to 80.4%. Chemotherapeutic agents were potential risk factors for OM in eight (42%) studies. Hematological, hepatic, and renal parameters were also considered in eight (42%) studies, while specific individual factors were reported in five (26.3%) studies. Baseline disease, oral microbiota, genetic profile, and biomarkers were reported in four (21.5%) studies each. Meta-analysis showed that groups submitted to high-risk chemotherapy for OM had a 2.79-fold increased risk of OM.
Conclusions: Identifying risk factors for OM is essential in order to allow individualized and early prevention treatment.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: