Pharmaceutical applications of starch nanoparticles: A scoping review.

Autor: Caldonazo A; Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Parana, Curitiba 80210-170, PR, Brazil. Electronic address: caldonazo.aline@gmail.com., Almeida SL; Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Parana, Curitiba 80210-170, PR, Brazil., Bonetti AF; Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Parana, Curitiba 80210-170, PR, Brazil., Lazo REL; Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Parana, Curitiba 80210-170, PR, Brazil., Mengarda M; Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Parana, Curitiba 80210-170, PR, Brazil., Murakami FS; Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Parana, Curitiba 80210-170, PR, Brazil.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2021 Jun 30; Vol. 181, pp. 697-704. Date of Electronic Publication: 2021 Mar 22.
DOI: 10.1016/j.ijbiomac.2021.03.061
Abstrakt: Starch nanoparticles (SNPs) have been applied to different areas of material sciences, especially in pharmaceuticals due to their characteristics such as small particle size, high surface ratio-volume, and biological compatibility. However, in pharmaceutical sciences, there are no records of a scoping review that had extensively mapped all available information about SNPs. A scoping review was performed here by searching electronic databases (Pubmed and Science Direct) to identify studies published previous to June 2020. From 699 total records, 37 matched the criteria for inclusion. The findings showed that SNPs have been used, not only for the development of different active pharmaceutical ingredient delivery systems, but also as an enzyme inhibitor, adsorption, and DNA precipitation agent. In conclusion, by combining different starch sources and methods SNPs show a remarkable diversity in pharmaceutical applications. Future studies should explore SNPs safety and provide information about variables that may affect important properties for this kind of application.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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