| Autor: |
Marinho BM; Laboratory of Phytochemistry - Department of Pharmacy, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG, Brazil., Fernandes DN; Laboratory of Phytochemistry - Department of Pharmacy, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG, Brazil., Chicoti MZ; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo - UNIFESP, Diadema, SP, Brazil., Ribeiro GJG; Laboratory of Phytochemistry - Department of Pharmacy, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG, Brazil., Almeida VG; Laboratory of Immunology - Department of Pharmacy, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG, Brazil., Santos MGD; Laboratory of Immunology - Department of Pharmacy, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG, Brazil., Guimarães VHD; Laboratory of Health Science, Postgraduate Program in Health Science, Universidade Estadual de Montes Claros (Unimontes), Montes Claros, MG, Brazil., Marchioretto MS; Herbarium PACA/Anchietano Research Institute, University of Bells River Valley (UNISINOS), São Leopoldo, RS, Brazil., Martins HR; Laboratory of Phytochemistry - Department of Pharmacy, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG, Brazil., de Melo GEBA; Laboratory of Immunology - Department of Pharmacy, Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, MG, Brazil., Gregorio LE; Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo - UNIFESP, Diadema, SP, Brazil. |
| Abstrakt: |
Gomphrena virgata Mart. popularly known as 'Cangussu-branco', is used in Brazilian folk medicine to treat inflammations and infections. This work aimed to carry out phytochemical analysis and evaluate the anti-inflammatory potential of Gomphrena virgata . In the phytochemical investigation, in addition to the presence of two ecdysteroids, 20 R-dihydroxyecdysone and 20-hydroxyecdysone, identified by HPLC-PDA-MS and NMR, 22 compounds were identified by GC-MS. In the cytotoxicity study, the aqueous extract of the roots of this species did not show in vitro toxicity of PBMCs in the concentrations of 250, 500 and 1000 µg/mL when analyzed by the trypan blue exclusion method. Also, it was effective in reducing lymphocyte proliferation, stimulated with the mitogen PHA, by 26.02%, 48.57% and 50.49% when compared to dexamethasone, respectively. In this work we present information about the phytochemicals of G. virgata , showing that the species is promising in obtaining compounds with medicinal potential mainly anti-inflammatory potential. |
