A Case Report of Acquired Factor X Deficiency in a Patient With Multiple Myeloma.
| Autor: | Sabobeh T; Internal Medicine, University of Missouri Kansas City, Kansas City, USA., Brugioni EK; Hematology and Oncology, University of Missouri Kansas City, Kansas City, USA., Masoud A; Internal Medicine, University of Missouri Kansas City, Kansas City, USA., Madhusudhana S; Hematology and Oncology, University of Missouri Kansas City, Kansas City, USA., Mateescu V; Pathology, University of Missouri Kansas City, Kansas City, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2021 Feb 11; Vol. 13 (2), pp. e13293. Date of Electronic Publication: 2021 Feb 11. |
| DOI: | 10.7759/cureus.13293 |
| Abstrakt: | Multiple myeloma is a plasma cell neoplasm characterized by clonal proliferation of immunoglobulin producing terminally differentiated B cells. Classically patients are described to present with bone pain, hypercalcemia, anemia, and/or renal impairment. A less described clinical manifestation related to the myeloma is acquired coagulation abnormalities including paraprotein interfering with the coagulation cascade or exhibiting specific antibody activity. Factor X deficiency is reported in patients with secondary amyloidosis. We describe a patient who presented with bleeding tendency and an abnormal prothrombin and activated partial thromboplastin times (PT/PTT) due to factor X deficiency. A thorough workup revealed the diagnosis of multiple myeloma with the presence of monoclonal lambda light chain restricted plasma cells with qualifying end-organ damage without evidence of amyloidosis. Prior to the ultimate diagnosis, the patient succumbed to septic shock and acute respiratory distress syndrome due to Streptococcus Pneumonia infection. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Sabobeh et al.) |
| Databáze: | MEDLINE |
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