Identifying Risk Factors That Distinguish Symptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection From Common Upper Respiratory Infections in Children.

Autor:	Schneider JG; Department of Infectious Diseases, Indiana University School of Medicine, Indianapolis, USA., Relich RF; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA., Datta D; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA., Bond C; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA., Goings M; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA., Hall D; Department of Internal Medicine and Pediatrics, Indiana University School of Medicine, Indianapolis, USA., Lei GS; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA., Kedra J; Department of Pathology and Laboratory Medicine, Indiana University Health, Indianapolis, USA., John CC; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Feb 10; Vol. 13 (2), pp. e13266. Date of Electronic Publication: 2021 Feb 10.
DOI:	10.7759/cureus.13266
Abstrakt:	Background Demographic and clinical risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children presenting with respiratory viral symptoms are not well defined. An understanding of risk factors for SARS-CoV-2 infection can help prioritize testing. Methodology We evaluated potential demographic and clinical factors in children who had respiratory viral symptoms and were tested by polymerase chain reaction (PCR) for SARS-CoV-2 and other respiratory viral infections. Results Among the 263 symptomatic children tested for routine seasonal respiratory viruses by PCR, 18 (6.8%) tested positive for SARS-CoV-2. Overall, 22.2% of SARS-CoV-2-infected children and 37.1% of SARS-CoV-2-uninfected children had infection with one or more non-SARS-CoV-2 pathogens (p = 0.31). Higher proportions of children with compared to without SARS-CoV-2 infection were male (77.8 vs. 51.8%, p = 0.05), Hispanic (44.4% vs. 9.8%, p < 0.001), or had the symptoms of fatigue (22.2% vs. 2.5%, p = 0.003) or anosmia/ageusia (11.1% vs. 0%, p = 0.004). History of hypoxic-ischemic encephalopathy (HIE) and obesity were more common in children with versus without SARS-CoV-2 infection (11.1% vs. 1.2%, p = 0.04, and 11.1% vs. 0%, p = 0.004, respectively). In a multivariate analysis, Hispanic ethnicity, symptoms of fatigue or anosmia/ageusia, and presence of obesity (as noted on physical examination) or HIE were independently associated with SARS-CoV-2 infection. Numbers in each category were small, and these preliminary associations require confirmation in future studies. Conclusions In this area of the United States, infection with other viruses did not rule out infection with SARS-CoV-2. Additionally, children with respiratory viral symptoms who were of Hispanic ethnicity, had symptoms of weakness/fatigue, or had obesity or HIE were at an increased risk for SARS-CoV-2 infection. Future studies should assess if these factors are associated with risk in populations in other areas of the United States. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Schneider et al.)
Databáze:	MEDLINE
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