Tumor aggressiveness is independent of radiation quality in murine hepatocellular carcinoma and mammary tumor models.

Autor: Udho EB; Promega Corporation, Madison, WI, USA., Huebner SM; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI, USA., Albrecht DM; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI, USA., Matkowskyj KA; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, USA.; William S. Middleton VA Medical Center, Madison, WI, USA., Clipson L; Department of Oncology, University of Wisconsin, Madison, WI, USA., Hedican CA; Promega Corporation, Madison, WI, USA., Koth R; Promega Corporation, Madison, WI, USA., Snow SM; Department of Oncology, University of Wisconsin, Madison, WI, USA., Eberhardt EL; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI, USA., Miller D; Promega Corporation, Madison, WI, USA.; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI, USA., Van Doorn R; Promega Corporation, Madison, WI, USA.; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI, USA., Gjyzeli G; Promega Corporation, Madison, WI, USA.; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI, USA., Spengler EK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI, USA., Storts DR; Promega Corporation, Madison, WI, USA., Thamm DH; Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA., Edmondson EF; Molecular Histopathology Lab, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Weil MM; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA., Halberg RB; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI, USA.; Carbone Cancer Center, University of Wisconsin, Madison, WI, USA.; Department of Oncology, University of Wisconsin, Madison, WI, USA., Bacher JW; Promega Corporation, Madison, WI, USA.; Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin, Madison, WI, USA.
Jazyk: angličtina
Zdroj: International journal of radiation biology [Int J Radiat Biol] 2021; Vol. 97 (8), pp. 1140-1151. Date of Electronic Publication: 2021 Mar 31.
DOI: 10.1080/09553002.2021.1900946
Abstrakt: Purpose: Estimating cancer risk associated with interplanetary space travel is complicated. Human exposure data to high atomic number, high-energy (HZE) radiation is lacking, so data from low linear energy transfer (low-LET) γ-ray radiation is used in risk models, with the assumption that HZE and γ-ray radiation have comparable biological effects. This assumption has been challenged by reports indicating that HZE radiation might produce more aggressive tumors. The goal of this research is to test whether high-LET HZE radiation induced tumors are more aggressive.
Materials and Methods: Murine models of mammary and liver cancer were used to compare the impact of exposure to 0.2Gy of 300MeV/n silicon ions, 3 Gy of γ-rays or no radiation. Numerous measures of tumor aggressiveness were assessed.
Results: For the mammary cancer models, there was no significant change in the tumor latency or metastasis in silicon-irradiated mice compared to controls. For the liver cancer models, we observed an increase in tumor incidence but not tumor aggressiveness in irradiated mice.
Conclusion: Tumors in the HZE-irradiated mice were not more aggressive than those arising from exposure to low-LET γ-rays or spontaneously. Thus, enhanced aggressiveness does not appear to be a uniform characteristic of all tumors in HZE-irradiated animals.
Databáze: MEDLINE
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