Massive intrasplenic arterial thrombosis in a patient with chronic ITP during the development of an Evans syndrome.

Autor: Diez-Feijóo R; Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Rodríguez-Sevilla JJ; Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. Electronic address: 63639@parcdesalutmar.cat., Colomo L; Department of Pathology, Hospital del Mar, Barcelona, Spain., Papaleo N; Department of Pathology, Hospital del Mar, Barcelona, Spain., Maiques JM; Department of Radiology, Hospital del Mar, Barcelona, Spain., Gimeno E; Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Andrade-Campos M; Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Abella E; Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Merchan BM; Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Calvo X; Department of Pathology, Hospital del Mar, Barcelona, Spain., Jimenez C; Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Román-Bravo OD; Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Salar A; Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Sanchez-Gonzalez B; Department of Hematology, Hospital del Mar, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Jazyk: angličtina
Zdroj: Thrombosis research [Thromb Res] 2021 Dec; Vol. 208, pp. 226-229. Date of Electronic Publication: 2021 Feb 24.
DOI: 10.1016/j.thromres.2021.02.021
Abstrakt: Long-term safety and efficacy of eltrombopag in adults with persitent/chronic primary immune thrombocytopenia (ITP) evaluated in EXTEND study, showed a high response rate (80%) but, in the clinical safety study, it was observed that 6% of the patients presented venous and arterial thrombotic events. In addition, in the course of the disease, autoimmune hemolytic anemia (Evans syndrome, ES) may occur and could increase the risk of thrombosis. We report an interesting case of splenic rupture due to massive intrasplenic arterial thrombosis in the course of ES in a patient with chronic ITP treated with eltrombopag. The purpose of this case report is to highlight the potential increase in thrombotic risk that may involve the use of eltrombopag in hemolysis situations in patients with ITP.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: