Physical Activity, Inflammation, Coronary Artery Calcification, and Incident Coronary Heart Disease in African Americans: Insights From the Jackson Heart Study.

Autor:	Kamimura D; Department of Medicine, University of Mississippi Medical Center, Jackson; Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan. Electronic address: daisukekmmr@gmail.com., Cain-Shields LR; Department of Data Sciences, University of Mississippi Medical Center, Jackson., Clark D; Department of Medicine, University of Mississippi Medical Center, Jackson., Oshunbade AA; Department of Medicine, University of Mississippi Medical Center, Jackson., Ashley KE; Department of Medicine, University of Mississippi Medical Center, Jackson., Guild CS; Department of Medicine, University of Mississippi Medical Center, Jackson., Loprinzi PD; Center for Health Behavior Research, University of Mississippi, University., Newton R; PA & Ethnic Minority Health Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA., Blaha MJ; Johns Hopkins Ciccarone Center for Prevention of Heart Disease, Baltimore, MD., Suzuki T; Department of Medicine, Indiana University School of Medicine, Indianapolis., Butler J; Department of Medicine, University of Mississippi Medical Center, Jackson., Hall JE; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson., Hall ME; Department of Medicine, University of Mississippi Medical Center, Jackson; Department of Physiology and Biophysics, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson.
Jazyk:	angličtina
Zdroj:	Mayo Clinic proceedings [Mayo Clin Proc] 2021 Apr; Vol. 96 (4), pp. 901-911. Date of Electronic Publication: 2021 Mar 10.
DOI:	10.1016/j.mayocp.2020.09.042
Abstrakt:	Objective: To examine associations between physical activity (PA), inflammation, coronary artery calcification (CAC), and incident coronary heart disease (CHD) in African Americans. Methods: Among Jackson Heart Study participants without prevalent CHD at baseline (n=4295), we examined the relationships between PA and high-sensitivity C-reactive protein, the presence of CAC (Agatston score ≥100), and incident CHD. Based on the American Heart Association's Life's Simple 7 metrics, participants were classified as having poor, intermediate, or ideal PA. Results: After adjustment for possible confounding factors, ideal PA was associated with lower high-sensitivity C-reactive protein levels (β, -0.15; 95% CI, -0.15 to -0.002) and a lower prevalence of CAC (odds ratio, 0.70; 95% CI, 0.51-0.96) compared with poor PA. During a median of 12.8 years of follow-up, there were 164 incident CHD events (3.3/1000 person-years). Ideal PA was associated with a lower rate of incident CHD compared with poor PA (hazard ratio, 0.55; 95% CI, 0.31-0.98). Conclusion: In a large community-based African American cohort, ideal PA was associated with lower inflammation levels, a lower prevalence of CAC, and a lower rate of incident CHD. These findings suggest that promotion of ideal PA may be an important way to reduce the risk of subclinical and future clinical CHD in African Americans. (Copyright © 2020 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu