The human oral phageome.

Autor: Szafrański SP; Department of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, Germany., Slots J; Division of Periodontology, Diagnostic Sciences and Dental Hygiene, Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, California, USA., Stiesch M; Department of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, Germany.
Jazyk: angličtina
Zdroj: Periodontology 2000 [Periodontol 2000] 2021 Jun; Vol. 86 (1), pp. 79-96. Date of Electronic Publication: 2021 Mar 10.
DOI: 10.1111/prd.12363
Abstrakt: Oral bacteriophages (or phages), especially periodontal ones, constitute a growing area of interest, but research on oral phages is still in its infancy. Phages are bacterial viruses that may persist as intracellular parasitic deoxyribonucleic acid (DNA) or use bacterial metabolism to replicate and cause bacterial lysis. The microbiomes of saliva, oral mucosa, and dental plaque contain active phage virions, bacterial lysogens (ie, carrying dormant prophages), and bacterial strains containing short fragments of phage DNA. In excess of 2000 oral phages have been confirmed or predicted to infect species of the phyla Actinobacteria (>300 phages), Bacteroidetes (>300 phages), Firmicutes (>1000 phages), Fusobacteria (>200 phages), and Proteobacteria (>700 phages) and three additional phyla (few phages only). This article assesses the current knowledge of the diversity of the oral phage population and the mechanisms by which phages may impact the ecology of oral biofilms. The potential use of phage-based therapy to control major periodontal pathogens is also discussed.
(© 2021 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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