Obesity is associated with an altered baseline and post-vaccination influenza antibody repertoire.

Autor:	Abd Alhadi M; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev; Beer-Sheva, Israel.; National Center for Biotechnology in the Negev, Ben-Gurion University of the Negev; Beer-Sheva, Israel., Friedman LM; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev; Beer-Sheva, Israel.; National Center for Biotechnology in the Negev, Ben-Gurion University of the Negev; Beer-Sheva, Israel., Karlsson EA; Virology Unit, Institute Pasteur du Cambodge; Phnom Penh, Cambodia.; Department of Infectious Diseases, St. Jude Children's Research Hospital; Memphis, TN, USA., Cohen-Lavi L; National Center for Biotechnology in the Negev, Ben-Gurion University of the Negev; Beer-Sheva, Israel.; Department of Industrial Engineering and Management, Ben-Gurion University of the Negev; Beer-Sheva, Israel., Burkovitz A; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev; Beer-Sheva, Israel.; National Center for Biotechnology in the Negev, Ben-Gurion University of the Negev; Beer-Sheva, Israel., Schultz-Cherry S; Department of Infectious Diseases, St. Jude Children's Research Hospital; Memphis, TN, USA., Noah TL; Department of Pediatrics, University of North Carolina at Chapel Hill; NC, USA., Weir SS; Department of Family Medicine, University of North Carolina at Chapel Hill; NC, USA., Shulman LM; Dept. of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University; Tel Aviv, Israel., Beck MA; Department of Nutrition, Gillings School of Global Public Health, UNC, Chapel Hill; NC, USA., Hertz T; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev; Beer-Sheva, Israel.; National Center for Biotechnology in the Negev, Ben-Gurion University of the Negev; Beer-Sheva, Israel.; Vaccine and Infectious Disease Division, Fred Hutch Cancer Research Center; Seattle, WA, USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2021 Mar 05. Date of Electronic Publication: 2021 Mar 05.
DOI:	10.1101/2021.03.02.21252785
Abstrakt:	As highlighted by the ongoing COVID-19 pandemic, vaccination is critical for infectious disease prevention and control. Obesity is associated with increased morbidity and mortality from respiratory virus infections. While obese individuals respond to influenza vaccination, what is considered a seroprotective response may not fully protect the global obese population. In a cohort vaccinated with the 2010-2011 trivalent inactivated influenza vaccine, baseline immune history and vaccination responses were found to significantly differ in obese individuals compared to healthy controls, especially towards the 2009 pandemic strain of A/H1N1 influenza virus. Young, obese individuals displayed responses skewed towards linear peptides versus conformational antigens, suggesting aberrant obese immune response. Overall, these data have vital implications for the next generation of influenza vaccines, and towards the current SARS-CoV-2 vaccination campaign. Competing Interests: Competing interests: The authors declare no non-financial interest but declare a competing financial interest. A patent application related to the microarrays used in this research has been filed by TH and LMF.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu